Nicoleta Andreea Toderas

Mrs. Nicoleta Andreea Toderas

orcid

Research Focus & Metrics

Academic Career Length

2Years (2025-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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21 April 2025 in Journal of Clinical Medicine
Verified
Journal Article
Open access
PDF file
VBVanessa Bolchis
Vanessa Bolchis
DJDaniela Elisabeta Jumanca
Daniela Elisabeta Jumanca
Ramona DumitrescuRamona Dumitrescu
Ramona Dumitrescu
OBOctavia-Iulia Bălean
Octavia-Iulia Bălean
NTNicoleta Andreea Toderas
Nicoleta Andreea Toderas
Atena GaluscanAtena Galuscan
Atena Galuscan
Background/Objectives: The bidirectional relationship between diabetes mellitus (DM) and periodontal disease (PD) has garnered increasing attention due to shared inflammatory mechanisms and mutual disease exacerbation. In Romania, despite a high prevalence of diabetes and PD, integration of oral health into diabetes care remains limited. This study aimed to investigate the association between glycemic control, salivary inflammatory biomarkers (IL-1β, IL-6, MMP-8), and periodontal status in diabetic patients. Additionally, it evaluated patients’ awareness of oral health risks and their communication with healthcare providers regarding periodontal care. Methods: A cross-sectional, observational study was conducted between May and December 2024, involving 79 adult patients with confirmed type 1 or type 2 DM. Periodontal examinations assessed probing pocket depth (PPD), clinical attachment level (CAL), plaque index (PI), and bleeding on probing (BOP). Salivary samples were collected to quantify IL-1β, IL-6, and MMP-8. Participants also completed a structured questionnaire on oral symptoms, hygiene practices, and awareness of the diabetes–periodontitis link. Correlation and t-test analyses were used to explore associations between clinical, biochemical, and self-reported variables. Results: Most participants had advanced periodontitis (65.8% Stage IV; 72.2% Grade C). IL-1β and IL-6 were positively correlated (r = 0.34, p < 0.01), while MMP-8 correlated with PI (r = 0.28) and BOP (r = 0.26). Inflammatory markers showed weak correlation with HbA1c. Notably, patients with higher oral health knowledge reported worse clinical indices, suggesting increased symptom awareness rather than preventive effectiveness. Conclusions: This study reinforces the inflammatory link between DM and PD and highlights the need for integrated care models. Periodontal screening and education should be embedded within diabetes management, particularly in high-risk populations.

12 January 2025 in Journal of Clinical Medicine
Verified
Journal Article
Open access
PDF file
VBVanessa Bolchis
Vanessa Bolchis
IAIulia Alexa
Iulia Alexa
NTNicoleta Andreea Toderas
Nicoleta Andreea Toderas
Ramona DumitrescuRamona Dumitrescu
Ramona Dumitrescu
Ruxandra Sava-RosianuRuxandra Sava-Rosianu
Ruxandra Sava-Rosianu
DCDoina Chioran
Doina Chioran
Introduction: T2DM mellitus (T2DM) is a major global health issue associated with significant morbidity, mortality, and economic burden. While the role of lifestyle factors in glycemic control is well-established, the influence of oral health behaviors remains underexplored. Objective: This study aimed to investigate the interplay between lifestyle habits, oral health behaviors, and glycemic control in patients with T2DM. Methodology: A cross-sectional study was conducted on 132 patients (66 men and 66 women) with T2DM at the Pius Brînzeu Emergency Hospital in Timișoara, Romania. Data on smoking, physical activity, alcohol consumption, tooth brushing frequency, and dental visits were collected using structured questionnaires, and glycemic control was assessed through HbA1c measurements. Statistical analyses, including Pearson correlations and linear regression, were performed. Results: Among men, HbA1c levels were negatively associated with exercise frequency (ß = −0.26, p < 0.05) and education level (correlation coefficient −0.27, p < 0.05), and positively associated with dental visits and tooth brushing frequency (correlation coefficient 0.26, p < 0.05). In the combined analysis, education level positively correlated with both dental visits (correlation coefficient 0.24, p < 0.01) and alcohol consumption (correlation coefficient 0.22, p < 0.05). Conclusions: These findings underscore the importance of integrating oral health and lifestyle interventions into diabetes management to optimize patient outcomes.

25 March 2025 in Medicina
Verified
Journal Article
Open access
PDF file
Ramona DumitrescuRamona Dumitrescu
Ramona Dumitrescu
PIPetculescu Iasmina-Madalina
Petculescu Iasmina-Madalina
COCarmen Opriș
Carmen Opriș
Vlase TitusVlase Titus
Vlase Titus
GVGabriela Vlase
Gabriela Vlase
OBOctavia-Iulia Bălean
Octavia-Iulia Bălean
Background and Objectives: Resin composites are widely used in restorative dentistry due to their favorable mechanical properties and aesthetics. However, their clinical performance depends on factors such as chemical composition, microhardness, and exposure to environmental challenges like acidic beverages. Materials and Methods: This study evaluated the effects of coffee, red wine, and Coca-Cola on the surface microhardness and chemical composition of two resin composites (G-ænial A’CHORD and Omnichroma). A total of 40 disk-shaped specimens (20 per composite) were fabricated and divided into four groups: control, red wine, coffee, and Coca-Cola. Specimens were immersed in their respective solutions for 10 days, after which Raman spectroscopy, Fourier Transform Infrared (FTIR) spectroscopy and Vickers microhardness testing were conducted to assess mechanical and chemical changes. Paired t-tests were performed to compare pre- and post-immersion values, with significance set at p < 0.05. Raman and FTIR spectroscopy confirmed structural changes, including peak shifts and intensity variations, particularly in polymer–matrix interactions and filler compositions. Results: The Vickers microhardness test revealed significant reductions in hardness for both composites after immersion, with Omnichroma showing a greater susceptibility to softening than G-ænial A’CHORD (p < 0.01). Red wine and coffee immersion resulted in the most significant decreases, indicating the strong impact of polyphenolic and acidic interactions on the composite structure. Conclusions: These findings indicate that prolonged exposure to acidic and staining beverages compromises the mechanical and chemical integrity of resin composites, with Omnichroma being more affected than G-ænial A’CHORD. The findings suggest that the selection of composite materials should consider resistance to staining agents, especially in high-risk oral environments.

7 May 2025 in Methods and Protocols
Verified
Journal Article
Open access
PDF file
Ruxandra Sava-RosianuRuxandra Sava-Rosianu
Ruxandra Sava-Rosianu
Guglielmo CampusGuglielmo Campus
Guglielmo Campus
Vlad-Tiberiu AlexaVlad-Tiberiu Alexa
Vlad-Tiberiu Alexa
OBOctavia-Iulia Bălean
Octavia-Iulia Bălean
Ionela Ruxandra SfeatcuIonela Ruxandra Sfeatcu
Ionela Ruxandra Sfeatcu
Atena GaluscanAtena Galuscan
Atena Galuscan
Background: Oral diseases represent a constant burden for health care and socio-economic systems as they are correlated to other non-communicable diseases. The aim of the proposed intervention is to test the effect of daily tooth brushing and oral health education on the oral health status of kindergarten children. Methods: The protocol will be conducted based on a previous epidemiological survey and conducted over 24 months; it has been developed on different levels. Dental hygienists will receive specific training to deliver oral health promotion to children and nursery educators. Training will focus on tailoring key messages to the specific age at visit; this will be outlined in the care pathway and offer practical preparation for delivering interventions and a toothpaste/toothbrush scheme. It will also, involving involve offering free daily tooth brushing to every 4–6-year-old child attending nursery. Data will be collected in four kindergartens in the capital or metropolitan areas, two kindergartens each in two large cities, and one kindergarten each in four villages from different geographic areas. Procedures used to assess the outcomes of each activity will be tailored to specific outcomes. Daily tooth-brushing activities will be monitored using qualitative research. A cost analysis including the distribution of necessary materials and correct delivery of products that shows price trends and percentage differences over the time span as well as consumer price index evaluation for the given time span will be conducted. Clinical outcomes will be evaluated using the caries incidence rate; this will be calculated for each tooth as the unit of analysis and evaluated using a multi-step approach. Discussion: Downstream oral health prevention interventions, like clinical prevention and oral health promotion, aim to enhance children’s quality of life. The program’s goal is to progress towards upstream interventions for a more significant impact.