A great interest in agarose, with many health-promoting and gel properties, has been registered, especially in the field of bone regeneration and repair. Agarose and its major bioactive compounds are involved in biological activities such as inflammation, cell adhesion and proliferation, and the promotion of tissue repair. Due to its unique physical properties like gelation and solubility, agarose is increasingly utilized in the medical industry. The aim of this review is to present an overview of the applications of agarose hydrogels in bone tissue engineering, introducing agarose and its modified products as innovative solutions for bone regeneration. Additionally, the injectability of agarose hydrogels and their applications in bioprinting are also summarized. Data indicate that agarose will play an increasing role in current and future global medical sectors.

The precise management of chronic wounds poses a global medical challenge, owing to their complex and dynamically shifting pathological microenvironment, coupled with their inherent difficulty in healing. Traditional dressings, which lack capabilities for real-time monitoring and active intervention, fall short of meeting modern clinical needs. Composite hydrogels offer a novel solution to this problem. By integrating functional fillers within biocompatible hydrogel matrices, they form intelligent materials capable of sensing key wound parameters. This review systematically outlines the composite systems and material classification of such hydrogels designed for the intelligent monitoring of chronic wounds. It subsequently details the construction of multimodal monitoring systems and their applications across different types of chronic wounds., Finally, future development direction are discussed, aiming to advance the implementation of next generation, personalized intelligent wound management systems.