Background: Squamoid eccrine ductal carcinoma (SEDC) is an exceedingly rare and aggressive cutaneous adnexal malignancy, with fewer than 100 reported cases. Its histopathologic overlap with squamous cell carcinoma (SCC) frequently leads to misdiagnosis, delaying appropriate management. Unlike SCC, SEDC exhibits biphasic differentiation, deep infiltration, and a high rate of perineural invasion, contributing to significant morbidity and poor long-term outcomes. Given the absence of standardized treatment protocols, managing SEDC remains a challenge. Case Presentation: We report an unusual case of an 80-year-old female presenting with progressive numbness, nasal deviation, and a subcutaneous indurated lesion in the left nasofacial region. The early neurological symptoms were an atypical feature, suggesting perineural invasion (PNI) before visible tumor progression. Initial histopathologic evaluation was inconclusive, raising suspicion of SCC, necessitating immunohistochemical analysis, which confirmed ductal differentiation, leading to the final diagnosis of SEDC. The patient underwent radical resection with intraoperative margin assessment (Mohs micrographic surgery; MMS) followed by adjuvant radiotherapy (62 Gy/31 fractions) due to high-risk features, including perineural and perivascular invasion. Despite initial disease control, a local recurrence involving the left orbit and nasal bone occurred 20 months postoperatively, demonstrating the aggressive nature of SEDC despite clear surgical margins and adjuvant therapy. Due to disease progression and refusal of further surgery, only palliative care was provided. During follow-up, the patient contracted COVID-19, further complicating her clinical status and contributing to her demise. While COVID-19 was not directly linked to SEDC progression, its impact on patient management was significant. Conclusions: This case underscores the diagnostic and therapeutic challenges of SEDC, emphasizing the need for early suspicion, extensive histopathologic assessment, and aggressive multimodal treatment. The importance of multidisciplinary management—particularly in elderly and immunocompromised patients—and long-term surveillance due to high recurrence risk and PNI is crucial.

Background: Oral lipomas are uncommon benign tumors composed of mature adipocytes, accounting for roughly 1% of benign intraoral lesions. Common predilection sites are buccal mucosa, lips, and tongue, presenting as slow-growing, nodular masses, often with a yellow hue. As the size of most lesions does not exceed 10 mm, particularly larger lipomas may be misdiagnosed. We present two cases of large oral lipomas. Case reports: Case 1: A 58-year-old male with a painless, sessile nodular mass of approximately 2.5 cm in the left cheek, increasing in size and causing discomfort during mastication. After excision, histopathology revealed mature adipocytes with delicate fibrous septa. Case 2: A 47-year-old female with a tender yellow growth of approximately 2 cm in her lower lip, increasing in size and causing aesthetic problems with functional discomfort. After sharp dissection, the specimen presented acanthotic and parakeratotic epithelium with adipocytic tumorous tissue, permeated by collagenous cords. Conclusions: Oral lipomas are uncommon, mostly asymptomatic benign lesions. Mostly found in the buccal mucosa and lower lip, they can mimic more common growths. When located superficially, a conservative surgical excision leads to resolution with rare recurrences. Histopathological inspection is necessary to confirm the benign nature of the lesion.

Background/Objectives: This case report describes a rare case of bilateral coronoid hyperplasia (CPH) with suspected Jacob’s disease in a young female patient, managed by endoscopically assisted coronoidectomy, and provides quantitative oral-health-related quality of life (OHRQoL) and pain outcomes. Methods: An 18-year-old female with severely restricted mouth opening underwent bilateral endoscopically assisted intraoral coronoidectomy. OHRQoL and pain were assessed with the Oral Health Impact Profile 14 (OHIP-CRO14) and a 100 mm visual analogue scale (VAS) preoperatively, daily for seven postoperative days, and at one year. Results: Maximum mouth opening improved from 8 mm to 35 mm at nine months (+338%). OHIP-14 total scores remained within a “poor”-to-“moderate” impact and low quality of life from the preoperative value (38) throughout the postoperative week (31–38) and decreased to 14 at one year (−63%; “good” impact, very high quality of life). Psychological disability and psychological discomfort were the most affected domains. VAS scores rose from 36 preoperatively, peaked at 55 on day 2, fluctuated as mild pain (27–44), and resolved at one year. Conclusions: Endoscopically assisted intraoral coronoidectomy restored functional mouth opening and produced clinically meaningful improvements in pain and OHRQoL, with the largest gains in psychological domains. To the authors’ knowledge, this is the first case report providing quantified, domain-resolved OHRQoL outcomes after coronoidectomy.