My research aims to enhance the reproductive efficiency of livestock by elucidating the neuroendocrine mechanisms that regulate reproductive functions. Specifically, I investigate how the secretion of GnRH/LH from the hypothalamus and the downstream pituitary, which control gonadal function, is regulated. Using rats, goats, and cattle as model organisms, I focus on the physiological functions of kisspeptin neurons located in the hypothalamus. It is well known that reproductive functions are influenced by various exogenou factors such as nutritional status and stimuli from the opposite sex. My research explores how these exogenous factors regulate kisspeptin neurons, thereby controlling gonadal functions.