High rise building structures with podiums are widely present, and establishing a fast numerical prediction method to evaluate their wind-induced response characteristics is of great significance for engineering applications. This article proposes a process algo-rithm based on AR (autoregression) method to solve the time history of fluctuating wind speed and determine fluctuating wind load. The simulated fluctuating wind speed spectrum obtained through this algorithm matches the target wind speed spec-trum, and the wind-induced response characteristics of high-rise buildings with po-diums were studied using MIDAS GEN structural analysis software. In order to eval-uate the influence of different parameters on the wind-induced vibration response of high-rise buildings with podiums, a total of 11 comparative conditions were set, in-cluding the presence or absence of podiums, podium height, podium area, and podium layout conditions. A comprehensive time history analysis was conducted on the dis-placement, acceleration, shear force, and overturning moment of wind-induced vibra-tion response of high-rise buildings with podiums. The results indicate that in high-rise buildings with podiums, adding podiums and increasing their height and area can help suppress the inter story displacement of the main building and the inter story acceleration, inter story shear force, and intra story overturning moment of the middle and lower floors, which is beneficial for the safety and stability of the high-rise building structure. The layout of the podium has an impact on the wind-induced vibration re-sponse of the main building. When the podium and main building are symmetrically arranged in the downwind direction, the maximum displacement of each floor is small, while the maximum displacement curve of buildings with asymmetric layout at the junction of the podium and main building is not smooth. The design of the central layout of the podium and main building can effectively reduce the maximum shear force and maximum overturning moment of the higher floors of the building, but the effect is opposite at lower floors.