Southwestern China has abundant hydropower networks, wherein neighboring cascade hydropower stations within the same river basin are typically connected to the power system in a chain-structured configuration. However, when such chain-structured cascade hydroelectric power plants (CC-HPPs) participate in automatic voltage control (AVC), problems such as reactive power interactions among stations and unreasonable voltage gradients frequently arise. To address these issues, this study proposes an optimized multi-station coordinated response control strategy based on sensitivity analysis and hierarchical AVC. Firstly, based on the topology of the chain-structured hydropower sending-end network, a reactive power–voltage sensitivity matrix is constructed. Subsequently, a regional-voltage-coordinated regulation model is developed using sensitivity analysis, followed by the establishment of a mathematical model, solution algorithm, and operational procedure for multi-station AVC-coordinated response optimization. Finally, case studies based on the actual operational data of a CC-HPP network validate the effectiveness of the proposed strategy, and simulation results demonstrate that the approach reduces the interstation reactive power pulling up to 97.76% and improves the voltage gradient rationality by 16.67%. These results substantially improve grid stability and operational efficiency while establishing a more adaptable voltage control framework for large-scale hydropower integration. Furthermore, they provide a practical foundation for future advancements in multi-scenario hydropower regulation, enhanced coordination strategies, and predictive control capabilities within clean energy systems.