The aim of this study was to evaluate the histopathological features of primary extremity myxoid liposarcoma before and after neoadjuvant radiation therapy, and to evaluate the oncological outcomes of the patients. The study included 23 patients (16 men and 7 women with a mean age of 43 (24–69) years) with primary myxoid liposarcoma of the extremities, who were treated between January 1998 and December 2015. Inclusion criteria were histopathological confirmation of the diagnosis with both the initial biopsy and the resection specimen, and having undergone neoadjuvant radiotherapy. Demographic, clinical and histopathological data were evaluated. Over a mean follow-up time of 55.2 (8–139) months, 5 patients (21.7%) died secondary to disease progression, leaving 18 patients (78.3%) still alive at the time of last follow-up. Only one patient (4%) experienced local recurrence and six (26%) patients developed distant metastases. Disease-free survival at 5 and 10 years were 66%; whereas, overall patient survival at 5 and 10 years were 78.1% and 71.0%, respectively. Tumor size (>15 cm) and presence of metastasis were significantly associated with increased overall mortality. On histopathology, necrosis was present in 12/23 resection specimens. Hyalinization/fibrosis and residual viable tumor was present in all specimens. Adipocytic maturation/cytodifferentiation was seen in 8/23 patients. Neoadjuvant radiotherapy was effective for myxoid liposarcomas histopathologically, although these histopathological features did not affect the patients' oncological outcomes. Favorable oncological outcomes were obtained with neoadjuvant radiotherapy, surgical resection and chemotherapy. Level IV, therapeutic study.

This study compares the cyclic loading properties and failure loads of two screw combinations on a synthetic Schatzker type 1 tibia fracture model. Our hypothesis was that after adequate compression with first a partially threaded screw, addition of a fully threaded screw would provide more stability than an addition of a second partially threaded screw. The Schatzker type 1 tibial plateau fracture model was created. Fixation was obtained in group A (n = 10) with two partially threaded screws and in group B (n = 10) with one fully threaded screw and one partially threaded screw. Load-displacement evaluation was made at each 1000-cycle interval up to 10,000 cycles. Failure load was identified as the load creating a 2-mm displacement. Two-factor (groups and periods) repeated measurement analysis of variance and independent sample t tests were used. According to the two-factor repeated analysis, there was no significant difference for periods (p = 0.29) and time-period interaction (p = 0.59) (Wilk’s Lambda F value, 1.507 and 0.871, respectively). In the test of between-subject effects, there was no significant difference between groups in terms of cyclic loadings (p = 0.06, F = 4.065). However, in the t test for each 1000-cycle interval, the value of mean displacement in group B was significantly lower than that in group A in the initial, 1000-, 2000-, and 3000-cycle intervals (p = 0.023, 0.031, 0.025, 0.043, respectively). The mean displacement and standard deviations increased with the number of cycles. The mean range of displacement initially was 0.66 mm for group A and 0.36 mm for group B. The mean range of displacement after 10,000 cycles was 0.79 mm for group A and 0.44 mm for group B. The mean failure load value was 682 ± 234 N for group A and 835 ± 245 N for group B. In independent sample t tests, there were no significant differences between the two groups in terms of failure load (p > 0.05). Obtaining fixation with one partially and one fully threaded screw can minimize displacement at the fracture site at early cyclic loadings.

The fibular nerve is the most frequent site of neural entrapment in the lower extremity and the third most common site in the body, following the median and ulnar nerves. The peroneal nerve is commonly injured upon trauma. Additionally, a dropped foot might be a symptom related to the central nervous system or spinal pathologies in pediatric patients. Entrapment of the peripheral nerve as an etiologic cause should be kept in mind and further analyzed in orthopedic surgery clinics. In this study, the evaluation and treatment results of five patients with no history of trauma, who underwent diagnostic procedures and treatment in various clinics (physical therapy and rehabilitation and neurosurgery), are reported. The patients underwent several treatments without diagnosis of the primary etiology. Upon initial consultation at our department, osteochondroma at the proximal fibula was detected after physical examination and radiologic assessment. During surgery, the peroneal nerve was dissected, starting from a level above the knee joint. Following nerve release, the osteochondroma was removed, including its cartilage cap. Consequently, recovery was observed in all five cases after surgery. Many factors may cause non-traumatic neuropathies. However, due to their rare occurrence, lesions such as osteochondromas may be overlooked at non-orthopedic clinics. Nerve entrapment due to proximal fibular osteochondroma is rare. Surgical treatment planning plays a critical role in nerve entrapment cases. Despite its frequent occurrence, a drop foot associated with peroneal nerve entrapment by an osteochondroma is not easily remembered and diagnosed. Especially in pediatric cases, inadequate clinical consultation and a lack of appropriate radiologic studies may result in a delay in diagnosing peroneal nerve lesions.

Pavlik harness is the initial treatment for the infants with developmental dysplasia of the hip who have not yet begun walking. The present study evaluates the variables which affect the duration of PH treatment for patients successfully treated. Cross-sectional study. Pavlik harness was employed for 140 hips of 87 patients with developmental dysplasia of the hip in our institution between 2010 and 2013. In all, 55 hips of 46 patients who were treated successfully with Pavlik harness were included in this study. According to Graf’s sonographic classification, 23 hips were Type IIC, 26 were Type IID, and 6 were Type III. The studied variables were (1) alpha angle, (2) age at the start of treatment, (3) laterality, and (4) gender. The variables were compared with the duration of Pavlik harness treatment. A highly significant inverse correlation was observed between Pavlik harness application time and alpha angle at the start of the treatment (r = –0.050; p < 0.001). Bilateral involvement has statistically longer duration, when compared with unilateral involvement (r = 0.28; p = 0.036). No statistically significant difference was present between duration of treatment and age at the start of Pavlik harness treatment (r = –0.034; p = 0.804). There was no statistical significance between gender and duration of Pavlik harness (r = 0.201; p > 0.05). The duration of treatment was negatively correlated with the initial alpha angle. A change of 1 degree in alpha angle may alter the duration of treatment as 0.89 week calculated by the formula (Application time (Week) = 56.6 – 0.89 × alpha angle). Bilateral involvement may need longer Pavlik harness treatment. Pavlik harnes generally is the first treatment method for the infants with DDH. This study suggest conclutions about how long time is the Pavlik harness should be kept on the infants? The main indicator is initial alfa angle which is negatively correlated with the duration of treatment.