Topside choking is a common way to eliminate severe slugging flow in pipeline riser systems in offshore oil and gas fields. However, a lack of fundamentals in two-phase flow gives rise to difficulty in the model selection of valves and the effective control of the valves. In this study, the prediction of the valve opening required for slugging control based on measurable parameters is investigated experimentally and theoretically. It is found that the resistance coefficient factor of the valve is almost the same for pipeline risers and simple vertical pipes when severe slugging is eliminated. Therefore, fluid parameters can be approximated by the conditions of a simple vertical pipe. The target of control is to achieve dual-frequency fluctuation, and it is quantitatively converted to the pressure drop of the valve. Based on these two empirical enclosures, the valve opening can be worked out by using the gas fraction model and the theoretical model of valve flow resistance. The non-slip model is found to be better than the drift-flux model in the final prediction of the optimal valve opening. An explicit model for the calculation of the optimal resistance factor and the corresponding valve opening is established, making it more convenient to select the valve in the design stage of offshore oil and gas exploitation. The average absolute error of the proposed model is +0.01%, which is smaller than the simulation performed by OLGA 7.0 software (+4.91% before tuning and +0.08% after tuning). A field case with a flexible S-shape riser proves the good applicability of the model (with a deviation smaller than ±2%). The applications of the prediction model in the model selection of the valve and uncertain factors in the operation are also discussed.