Background: Premature hair graying (PHG) is one of the most prevalent conditions affecting individuals worldwide. It has been recognized as an important cause of low self-esteem, with a significant physical and social impact. This study investigated the factors associated with PHG by comparing medical students and resident physicians to other non-medical majors at Imam Abdulrahman Bin Faisal University (IAU). Methods: This is a comparative cross-sectional study conducted on resident physicians and students from 10 different colleges of IAU, Eastern Province, Saudi Arabia. This study evaluated the characteristics of PHG and its associated risk factors using an online distributed questionnaire. Results: A total of 2644 students and resident physicians were included in this study, with 45.6% coming from medical colleges. The findings show that the premature graying of hair was higher among obese and overweight individuals and those with a combined deficiency of vitamins B12 and vitamin D. Other factors associated with PHG included a family history of PHG, a lack of exercise, smoking, and allergic rhinitis. Gray hair onset before 25 years old was higher among those with high stress levels (95%) than those with moderate (90%) and or mild (86%) stress levels (p = 0.029). Conclusions: In our study, higher stress levels were related to an earlier age of PHG onset, and there was no difference between medical and non-medical students in PHG. Recommendations for future research include randomized clinical trials and larger cohort studies regarding the characteristics of PHG in the Middle East and those with Arabic ethnicity and assessing the medications that induce possible hair repigmentation.

Purpose: A global survey conducted by The International Society of Aesthetic Plastic Surgery (ISAPS) in 2022 reported 18.8 million non-surgical cosmetic procedures, with women representing 87%. Recent literature has shined a light on the possible implication of female sex hormones on the perception of pain, but the influence of these hormones on pain perception secondary to aesthetic procedures have scarcely been studied. Our study aimed to investigate the influence of the menstrual cycle on pain perception during non-surgical aesthetic procedures. The study explored the correlation between different phases of the menstrual cycle, the presence of premenstrual symptoms, and the severity of pain experienced by participants. Patients and Methods: A questionnaire-based cross-sectional study was conducted at dermatology clinics in Saudi Arabia. 383 complete responses were collected from participants who provided data on demographic factors, aesthetic procedures, menstrual status, premenstrual symptoms, and pain severity. Results: The 383 participants reported that the most frequent procedures were laser hair removal (82.5%) and injectables. Pain perception was highest for laser hair removal across all menstrual phases (4.5± 2.66, 4.8± 3.06 and 4.3± 3.48), and lowest for Ultherapy (1.56± 1.66, 1.40± 1.36 and 1.37± 1.37). Significant positive correlations were found between premenstrual symptom severity and pain perception in laser hair removal and injectables. Linear regression analysis revealed a significant negative association between age and pain perception in laser hair removal, while age had a positive association with other procedures. Conclusion: In conclusion, pain perception during non-surgical aesthetic procedures varies across menstrual phases and is influenced by the type of procedure. The negative relationship between age and pain in laser hair removal requires further research. These findings can help practitioners better manage patient expectations and experiences during these cosmetic treatments.

Psoriasis and rheumatoid arthritis (RA) are common chronic diseases with distinctive histological and molecular features. However, there are similarities in their immunological pathogenesis, leading to the use of some similar systemic biological treatment. In 5% of patients using biological therapy such as the anti-tumor necrosis factor alpha (anti-TNF-α), a paradoxical reaction (i.e., the exacerbation or development of one disease while treating the other) may develop. We report a case of a 27-year-old female diagnosed with seropositive RA who developed paradoxical psoriasis (PP) after the use of Adalimumab, an anti-TNF-α, and paradoxical eczema due to the use of Ixekizumab, an anti-interleukin-17A, for the treatment of PP. This case demonstrates the occurrence of two different types of paradoxical skin reactions in a single patient. This case also highlights the importance of the selection and cessation of biological treatment in similar cases, as well as the factors that might predict the development of paradoxical reactions to promote the safe usage of biological therapy.

Atopic dermatitis (AD) affects 5–20% of the global population, with moderate-to-severe cases frequently requiring systemic therapy. The introduction of Janus kinase inhibitors (JAKi) has transformed therapeutic options, warranting a comprehensive analysis of the evolving research landscape. This bibliometric and visualized review aimed to identify global research hotspots, collaboration networks, and influential contributors in JAKi-related AD research. Publications were retrieved from the Web of Science Core Collection (2014–2024) using the terms “(Janus kinase inhibitors OR JAK) AND (atopic dermatitis)”. Of 797 publications identified, 776 met inclusion criteria. Bibliometric mapping and visualization were conducted with VOSviewer, Excel, and Draw.io. The United States produced the most publications (34%), followed by Germany (12.62%), Japan (11.87%), and China (8.5%). The Icahn School of Medicine at Mount Sinai and Oregon Health & Science University led institutional output, while Kyoto University demonstrated the highest citation impact (82.57 citations per publication). Among authors, Emma Guttman-Yassky (25 publications) and Eric Simpson (22 publications) were the most prolific. Journal of Dermatological Treatment and Journal of the European Academy of Dermatology and Venereology were the leading publishing journals, while The Journal of Allergy and Clinical Immunology was the most co-cited. The most frequently cited reference was Oetjen (2017), with 674 citations. Keyword analysis highlighted “atopic dermatitis”, “JAK inhibitors”, “upadacitinib”, and “baricitinib” as central themes, with abrocitinib and biologics emerging as newer hotspots. This study provides an updated overview of global research activity on JAK inhibitors in AD, addressing knowledge gaps, collaboration patterns, and future directions in targeted therapy.