The status of central lymph node metastasis (CLNM) is crucial to determining the surgical strategies for papillary thyroid micro carcinoma (PTMC). The objective of the study was to establish a nomogram to predict the possibility of CLNM in PTMC patients. A total of 8668 PTMC patients who underwent total thyroidectomy or lobectomy with central lymph node dissection (CLND) from 2006 to 2016 were retrospectively retrieved. Univariate and multivariate analysis were performed to examine risk factors associated with CLNM. A nomogram for predicting CLNM was established and internally validated. Six variables significantly associated with CLNM were included in our model, these are age <55 years (odd ratio [OR] = 1.779, 95% confidence interval [CI],1.569-2.017; P < 0.001), male sex (OR = 1.718, 95%CI,1.543-1.913; P < 0.001), tumor size 0.5-1.0 cm (OR = 1.985,95%CI,1.761-2.238; P < 0.001), multifocal lesions (OR = 1.263, 95%CI,1.118-1.426; P < 0.001), extra thyroidal extension (ETE) (OR = 1.348, 95%CI,1.092-1.664; P = 0.005) and lateral lymph node metastasis (LLNM) (OR = 5.135, 95%CI, 4.236-6.225; P < 0.001). The discrimination of the prediction model was 0.711 (95%CI, 0.700-0.722; P < 0.001). Based on the quantified risk stratification offered by our nomogram, clinicians might have a thorough discussion with PTMC patients during the both pre- and postoperative period. Prophylactic CLND and strict postoperative evaluation may be indicated when the patients have a high nomogram score.

Objective: Extensive lateral neck dissection (LND), especially routine level V dissection, may potentially increase morbidity and have no significant benefit to survival in patients with papillary thyroid carcinoma (PTC). Our study aimed to determine the pattern and risk factors for level V lymph node metastasis (LNM) and to develop an assessment model based on a nomogram for predicting whether level V dissection is necessary.

Intrathyroidal thymic carcinoma (ITTC) is a rare malignant tumor that presents significant diagnostic and therapeutic challenges. Herein, we present the case of a 35-year-old woman with a right neck mass initially suspected to originate from the parathyroid but ultimately diagnosed as ITTC. This case illustrates the non-specific clinical manifestations of ITTC, the associated diagnostic difficulties, and emphasizes the essential role of pathological examination in diagnosis and guiding management.

Background: Lymphoepithelial carcinoma is an extremely rare malignant tumor in salivary glands, so it is of great significance to understand and summarize the disease characteristics and treatment experience. Methods: We reported 3 lymphoepithelial carcinoma cases undergoing surgical treatment and postoperative radiotherapy. Results: All cases were pathologically diagnosed with lymphoepithelial carcinoma of salivary gland after surgery, among which two had cervical lymph node metastasis. 2 cases have been followed up for 15 months without local recurrence or distant metastasis.1 cases has been followed up for 15 months,hepatic metastasis was diagnosed at the 8th month after postoperative radiotherapy, and received surgery for the liver lesion. Conclusion: Lymphoepithelial carcinoma of salivary gland has complex etiology and still needs a combined treatment based on surgery. Targeted therapy and immunotherapy may be used as new treatments in the future.