Chronic depression causes long-term structural and functional brain damage, making new effective therapies for depressed patients essential. Up to 30% of patients with depression are resistant to treatment and experience adverse effects. Alternative therapies may help achieve remission when used separately or with traditional therapies. Transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (tMS) are helpful therapeutic interventions for major depression (MMD). tDCS and tMS are noninvasive techniques that modulate the excitability of different brain regions. It has been shown to be safe and effective as monotherapy or in combination with other therapeutic interventions, such as antidepressants or psychotherapy. This review analyzes the current knowledge of using tDCS and tMS in animal models and clinical studies, both as monotherapy and/or combined with other therapeutic approaches.