The Lahore–Islamabad Motorway (M-2) is a critical transportation corridor in Pakistan, where contamination in roadside dust by potentially toxic elements (PTEs) presents potential environmental and health concerns. This study evaluates the concentration, spatial distribution, and ecological risks of PTEs (Mn, Ni, Cr, Cu, Pb, Zn, Cd, Ag, Fe) in road dust along the M-2. PTE concentrations were determined using standard protocols and by analysis using an atomic absorption spectrometer. The findings indicate substantial variability in metal concentrations, with Fe (CV% = 9.35%) and Pb (CV% = 7.06%) displaying the highest consistency, whereas Ni exhibited the greatest fluctuation (CV% = 168.80%). Contamination factor analysis revealed low to moderate contamination for Ni and Fe, while Zn contamination was significant in 60% of samples. Cr and Cd exhibited persistently high contamination, and Pb was uniformly elevated across all locations. Ecological risk assessment categorized Ni, Zn, and Cu as low-risk elements, while Pb posed a substantial risk. Cd concentrations indicated high to extreme ecological hazards, emphasizing the necessity for urgent mitigation measures. Factor analysis suggested an interaction of various sources, including industrial, vehicular emissions, and construction materials. Strengthened pollution control strategies and systematic monitoring are essential for mitigating contamination and ensuring environmental sustainability along the motorway.