Climate variability and ongoing warming trends increasingly influence grapevine phenology, grape composition, and wine quality in both traditional and emerging viticultural regions. This chapter provides an integrated overview of the main climatic factors affecting viticulture, with emphasis on temperature increases, precipitation variability, and water stress, and their effects on grapevine development, berry composition, and wine sensory expression. International literature is combined with regional experimental observations obtained in the Iași vineyard (Copou Viticultural Center, northeastern Romania), using the local cultivar Golia as a representative case study. Recent climatic conditions were associated with accelerated phenological development, earlier budburst and veraison, increased sugar accumulation, and reduced acidity. Warmer vintages generally promoted higher alcoholic strength, fuller sensory structure, and riper aromatic expression, whereas cooler or wetter years preserved greater acidity, freshness, and floral-mineral sensory characteristics. The results indicate that increasing thermal resources and hydroclimatic variability progressively modify wine compositional balance and sensory typicity under continental conditions. This chapter also discusses adaptive viticultural strategies, including canopy management, irrigation optimization, training system adjustment, and varietal selection, highlighting their importance for maintaining vineyard sustainability and wine quality under future climate scenarios.