Mycobacterium tuberculosis can spread through the entire body but rarely involves the eye. We report a patient with endophthalmitis in one eye and simultaneous retinal vasculitis in the fellow eye. Systemic work-up suggested infective endopericarditis. Polymerase chain reaction analyses of the vitreous and pericardial fluid were positive for M. tuberculosis. We initiated a four-drug antituberculous treatment regimen (isoniazid, ethambutol, pyrazinamide, and rifampin). After two weeks, we discontinued all the medications due to drug-induced hepatitis. We restarted isoniazid and rifampin, but hepatitis recurred. Finally, we chose isoniazid/ethambutol combination for 18 months, and also administered short-term systemic corticosteroid. His vision improved considerably with no recurrence of hepatitis or tuberculosis for 3 years after completion of treatment. Ocular tuberculosis can masquerade as other causes of intraocular inflammation, and a medical team consisting of an ophthalmologist and an infectious disease specialist might be needed for the diagnosis and management.

In this paper, an unrelated parallel machine scheduling problem with job (product) and machine acceptance and renewable resource constraints was considered. The main idea of this research was to establish a production facility without (or with minimum) investment in machinery, equipment, and location. This problem can be applied to many real problems. The objective was to maximize the net profit; that is, the total revenue minus the total cost, including fixed costs of jobs, job transportation costs, renting costs of machines, renting cost of resources, and transportation costs of resources. A mixed-integer linear programming (MILP) model and several heuristics (greedy, GRASP, and simulated annealing) are presented to solve the problem.