This study poses the following research question: Where and how can low- to medium-enthalpy geothermal resources in Northern México be harnessed to promote a territorially anchored, socially inclusive energy transition? Hence, the potential contribution of geothermal direct uses to sustainable local development in Sonora—one of México’s largest and most economically diverse states—is examined in this article. In Sonora, a semi-arid region with dispersed populations and underutilized geothermal resources, the research integrates spatial analysis and socio-territorial indicators to identify areas where geothermal direct uses can deliver inclusive development benefits. Thermal data of 88 thermal springs and 36 wellbores were examined, in which in situ temperatures and geothermal gradients were found from 30 to 80 °C and 20–200 °C/km, respectively. This resulted in a catalog of 28 direct uses based on the energy needs and demands of the population near the sites. Then, a composite methodological framework was developed that combined the Geothermal Suitability Index (GSI), the Socio-Productive Energy Demand Index (SPEDI), and the Territorial Vulnerability Index (TVI). These indices and the catalog were overlaid to detect municipalities where high geothermal potential, energy needs, and social vulnerability intersect. Results show that sites such as Bacadehuachi, Cajeme, and Fronteras offer high-priority opportunities for agri-food processing, aquaculture, and heating/cooling applications. The findings contribute to broader debates on rural energy access, energy justice, and decentralized planning, providing evidence-based guidance for policy design that aligns renewable energy deployment with regional equity and resilience goals.