Objectives: The primary objective of this review is to analyze the effects on body weight of discontinuing therapy with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) or tirzepatide in patients treated for obesity. In recent months, there has been a considerable increase in the utilization of GLP-1 RAs and GIP/GLP-1 RAs. However, the paucity of available data regarding their medium- to long-term safety remains a salient concern. Of particular significance is the observation of the weight curve following their suspension, a subject that has received scant attention to date. Methods: For this, a bibliographic search was carried out in three electronic databases: PubMed, Cochrane Library and Google Scholar. The following filters were applied: in the last 10 years, Randomized Controlled Trial, Adult: 19+ years. The review was restricted to randomized controlled trials to reduce bias and ensure the high quality of the studies examined. A total of 427 references were identified, 178 articles were read in full, and 13 articles were included in the analysis. Results and Conclusions: The analysis showed a rapid regain of weight after cessation of therapy, regardless of the duration of the treatment with GLP-1 RA or GIP/GLP-1 RA. This rebound is likely to substantially mitigate the metabolic benefits attained through weight loss. Given the efficacy of these drugs, it is essential for future research to focus on elucidating the optimal duration of these treatments or identifying techniques or schemes that involve a reduction in dosages to prevent weight regain.

Background: Nutritional therapy improves prognosis by reducing morbidity and mortality in malnourished hospitalised patients. To determine the occurrence of hospital malnutrition, it is essential to verify healthcare organisations’ ability to identify at-risk patients, considering that malnutrition is often hard to recognise without adequate screening. Methods: The aim of this study is to analyse the temporal evolution in hospitalised patients’ malnutrition, documented as diagnosis discharge letters, over an 11-year period (2014–2024) in four acute care hospitals, with a combined mean of 38,000 inpatients per year. Binomial regression and interrupted time series analysis were used to evaluate temporal evolution in the identification of malnutrition, particularly in relation to the introduction of a nutritional service in 2017. Results: Malnutrition diagnoses increased steadily across hospitals and within internal medicine and surgery departments. Interrupted time series analysis showed a significant rise in diagnostic odds post-intervention, especially in internal medicine. A plateau was observed in the last 3 years, with a mean prevalence of malnutrition of 18.2% for internal medicine (95% CI: 13.6–22.9) and 4.1% for surgery (95% CI: 0.5–7.6). Without the nutritional service, these results likely only would have been reached by 2031 in internal medicine and 2024 in surgery, suggesting an advancement of about eight years in medical wards. Conclusions: The introduction of a nutritional team has probably accelerated and improved the ability to quickly identify and therefore treat malnourished inpatients.