The problems on designing time-optimal motion profile in the motion system with elasticity are briefly reviewed. Related positioning error and robustness constraints are constructed based on the analytic envelope of residual vibration response which is formulated by the proposed energy-based approach. The time-optimal model under such constraints is applied in the proposed freeform S-curve profile, which is the superset of symmetric S-curve and AS-curve profiles, and to minimize the positioning time while keeping positioning accuracy under a neighborhood range of modeling frequency. The optimized motion profile shows that the proposed freeform S-curve profile allows the time-optimal model to simultaneously optimize the magnitude and phase terms in residual vibration response in order to obtain an optimal trade-off between shortening positioning time and keeping positioning accuracy. The experiment results show that the proposed optimization model can significantly reduce the positioning time compared with traditional S-curve under the same physical limits. The universality of the optimization model is verified by experiments with short distance and long distance cases. The robustness of the proposed optimization model is also validated by these experiments. Moreover, the analysis on the optimized freeform S-curve profile reveals that perfect waveform cancellation is not always necessary to limit the residual vibration.

Chemotherapy is generally accompanied by undesirable side effects, such as immunosuppression and malnutrition, which reduce tolerance to cancer therapies. Prior studies have shown that immunonutrition improves the clinical outcomes of cancer patients. In this study, immunoregulatory polysaccharides from Crassostrea hongkongensis were included in a nutrition formula that was administered to S180 tumor-bearing mice in combination with 5-fluorouracil (5-FU) treatment. The C_30–60% fraction of the polysaccharides was characterized as a branched polysaccharide, with a high amount of D-glucose (96.76% of the total) and the highest uronic acid and sulfate groups’ content among all of the polysaccharide fractions. The C_30–60% polysaccharide fraction showed a maximal proliferative effect on RAW264.7 cells and T lymphocytes at a concentration of 0.0391 mg mL⁻¹ and 0.0781 mg mL⁻¹, respectively. Moreover, the combination treatment of the C_30–60% polysaccharide-based nutrition formula (OPNF) with the administration of 5-FU effectively inhibited the growth of tumors and notably increased the leucocyte and lymphocyte counts in S180 tumor-bearing mice. In addition, a slight increase in the erythrocyte and hemoglobin values was observed in the mice treated with the combination of OPNF and 5-FU. These results suggest that supplementation with a C_30–60%-based enteral formula would be beneficial for patients undergoing chemotherapy with 5-FU.

The traditional Chinese medicine theory believes that octopus papaya soup can stimulate milk production in lactating women. The objective of this study was to determine whether dietary supplementation with an enzymatic hydrolysate of Octopus vulgaris and Carica papaya (EHOC) could increase milk production and nutritional indexes in Sprague Dawley (SD) rats. Female SD rats ( n = 24) were fed a control diet ( n = 8), EHOC-supplemented diet, or a positive control diet (Shengruzhi) from day 10 of pregnancy to day 10 of lactation. Maternal serum, mammary gland (day 10 of lactation), milk, and pup weight (daily) were collected for analysis. Results showed that the EHOC diet obviously elevated daily milk yield and pup weight compared to the control group ( P < .05). The EHOC diet was found to increase the concentration of prolactin (PRL), progesterone (P), estradiol (E ₂ ), and growth hormone (GH) significantly in the circulation and mammary gland. Mammary glands of EHOC-treated dams showed clear lobuloalveolar development and proliferation of myoepithelial cells, but no striking variations were observed among the groups. Furthermore, the nutrition content and immune globulin concentration in the milk of EHOC-supplemented dams were higher than those of the control group, especially the cholesterol, glucose, and IgG were higher by 44.98% ( P < .001), 42.76% ( P < .01), and 42.23% ( P < .01), respectively. In conclusion, this article demonstrates that EHOC administration has beneficial effects on milk production in the dams and on performance of the dam and pup. These results indicate that EHOC could be explored as a potentially lactogenic nutriment for lactating women.

A real time automatic optical inspection (AOI) system for printed circuit board (PCB) drill bit and the inspection methods are presented. After a brief comparison between traditional inspection methods and the AOI method, the outline of the AOI system configuration and inspection methods are described. Subsequently, the illumination method is discussed due to the special characteristics of drill bit blade for obtaining a clear and less distortion image. Based on the shape features of drill bit blade, inspection algorithms including edge extraction, edge subpixel location, line and curve fitting, corner detection and defect detection are investigated to enable inspection of 100% such drill bits including dimensional properties and surface defects for the drill bit blade. The test result demonstrates that the effectiveness of the developed inspection algorithms and the AOI method can meet the inspection requirements of PCB drill bits. Furthermore, AOI method makes the inspection for each drill bit available and increases the quality and the reliability of PCB drill bits