Background/Objectives : Periodontitis is a chronic inflammatory disease initiated by dysbiotic biofilms and driven by host immune dysregulation, leading to connective tissue destruction and alveolar bone loss. Its early diagnosis is closely linked to the progression and outcome of the disease. Active-matrix metalloproteinase-8 (aMMP-8) is one of the key biomarkers for estimating irreversible collagenolytic degradation. aMMP-8 is among the key biomarkers for estimating irreversible collagenolytic degradation. To evaluate the role of oral fluid/salivary/mouthrinse aMMP-8 tests for early detection and treatment monitoring of periodontitis. Methods: A search was conducted in the Medline, Embase, Scopus, and Cochrane databases, restricted to articles published between January 2020 and December 2024 to capture the most recent literature. Pilot, cohort, case–control, and cross-sectional studies were included, while studies not aligning with the objectives of this review, as well as narrative reviews, editorials, and opinions were excluded. Results: A total of 276 articles were retrieved. After removing duplicates, 226 studies remained, of which 216 were retained following title, abstract, and keyword screening. From these, 26 studies were finally included in this review. aMMP-8 point-of-care tests appear to be promising tools for early diagnosis, disease severity assessment, and treatment monitoring in periodontitis, though findings remain conflicting across studies. Elevated aMMP-8 levels are associated with active periodontal pathology and tissue destruction, reflecting ongoing collagenolytic degeneration. Conclusions: aMMP-8 mouthrinse, saliva, or oral fluid tests can be used for predictive and early diagnosis as well as for treatment monitoring in patients with periodontal disease, and they function effectively as biomarkers for periodontitis.

The pulp and periodontium are connected anatomically, functionally, and developmentally. It might be challenging to diagnose and arrange effective treatments when pulpal issues and inflammatory periodontal disease coexist. One of the most frequent oral cavity cysts is the radicular cyst, which is typically brought on by trauma or an infection. There are a number of techniques that are now being used to enhance postoperative recovery and hasten the repair and regeneration of the damaged area. An investigation revealed that a 38-years-old patient had a radicular cyst, which was initially treated by endodontic treatment of the involved teeth, followed by enucleation of the cyst and a further bone graft placement followed by Platelet rich fibrin membrane. The patient's main complaint was pain in lower front jaw region for two to three months. Patient also had few episodes of pus discharge on its own through the same region. After three months, there was an increase in clinical attachment level and a decrease in probing depth. There was a sizable bone fill, according to radiographic findings.