Background/Objectives: This study aims to evaluate the prevalence and degree of malnutrition among patients with type 2 diabetes mellitus using the CONUT and PNI scores. Hypothesis: The CONUT and PNI scores provide a reliable assessment of the nutritional status of patients with type 2 diabetes. Methods: The retrospective study was run at the Department of Internal, Autoimmune and Metabolic Diseases in the Central Clinical Hospital of the Medical University of Silesia in Katowice from January to December of 2022. From 266 patients diagnosed with diabetes, only 64 met the criteria and were included in this study. Results: We found varying degrees of malnutrition among patients. Only 20.3% of them were well nourished. Mild to moderate malnutrition was observed in, altogether, 67.2% of patients. Conclusions: The strong correlation between the CONUT and PNI (r = −0.88) indices confirms their diagnostic value. The introduction of the CONUT or PNI tools into routine practice should be considered in patients with T2DM, especially those over 65 years of age, but taking into account the significant limitations of these indices and the influence of various factors on the laboratory data considered.

Background: Vitamin D plays a crucial role in numerous physiological systems, including the muscular, immune, and endocrine systems, as well as calcium and bone homeostasis. Vitamin D deficiency, a global health problem affecting billions of people, is associated with adverse health outcomes and can serve as a marker for health status, disease severity, and length of hospital stay (LOS). Nutritional supplementation has been shown to be highly beneficial and is strongly recommended. Methods: In this study, the medical records of 834 hospitalized patients were retrospectively analyzed, with a focus on 25-hydroxyvitamin D [25(OH)D] levels. The patients were divided into groups based on serum vitamin D levels: deficient, suboptimal, adequate, and high. Correlations between vitamin D levels, LOS, laboratory parameters, comorbidities, seasonal variations, medical diagnosis of deficiency, and supplementation were examined. Results: Vitamin D deficiency was common and associated with a longer LOS. Women had higher vitamin D levels than men. No seasonal variation was observed. Only 14% of the patients took supplements before hospitalization, and 61% of the patients with vitamin D deficiency received supplementation. Conclusions: Routine vitamin D screening, tailored supplementation, and increased public awareness are essential to reduce hospitalizations, improve treatment outcomes, and promote independence among at-risk groups.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used in the treatment of type 2 diabetes and obesity due to their metabolic effects. Emerging evidence suggests they may also have neuroprotective effects, indicating their potential as disease-modifying therapies in neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Preclinical studies in animal models have demonstrated that GLP-1RAs can reduce neuroinflammation, oxidative stress, neuronal apoptosis, and pathological protein aggregation, while enhancing glucose metabolism and mitochondrial function. This narrative review analyzed results from human clinical trials evaluating GLP-1RAs in AD and PD, based on a search of four databases (Web of Science, Medline, Embase, and Clinical Trials). The analysis included eleven studies. In AD, clinical trials suggest that GLP-1RAs such as liraglutide and semaglutide may enhance brain glucose metabolism, facilitate glucose transport across the blood–brain barrier, and benefit neuronal networks. However, most studies did not demonstrate improvements in cognitive functions or radiological markers. Short-term clinical trials of GLP-1RAs, including exenatide and lixisenatide, demonstrated promising effects on motor and selected non-motor symptoms in patients with PD, but their disease-modifying effects remain unproven. GLP-1RAs showed a favorable safety profile. Despite promising findings, small study populations, heterogeneous protocols, and short observation periods limit definitive conclusions. Further larger, long-term studies are needed, particularly to clarify the risk–benefit balance, weight control, and long-term outcomes.

DOI: 10.20452/pamw.17098, Published online: August 26, 2025, Authors: Aleksandra Pilśniak, Agnieszka Jarosińska, Marta Pietrukaniec