Background and Objectives: Psoriasis vulgaris (PV) is a chronic inflammatory disease associated with oxidative stress. It has been reported that oxidative stress caused by disruption of redox signaling can cause molecular damage, activate dendritic cells, lymphocytes, and keratinocytes, and lead to angiogenesis, inflammation, cell necrosis, and apoptosis by increasing the levels of lipid peroxidation products. In this study, serum levels of asymmetric dimethylarginine (ADMA), malondialdehyde (MDA), and reduced glutathione (GSH) were analyzed to gain insight into the oxidative balance in patients with PV. Materials and Methods: This prospective study included 59 PV patients and 40 healthy volunteers as the healthy control group. Age, gender, body mass index (BMI), waist circumference, routine hematologic parameters [fasting blood glucose, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), blood lipid levels, hemogram parameters], disease duration, and disease severity were recorded on data forms. The levels of ADMA, MDA, and GSH were analyzed using the high-performance liquid chromatography (HPLC) method. Results: When analyzed in terms of demographic characteristics, no statistically significant difference was observed between the patient and control groups. When examined in terms of biochemical variables, white blood cell (WBC) values were found to be significantly higher in the patient group (t: 2.825; p < 0.05). Although waist circumference, BMI, glucose, CRP, ESR, lipids, platelet count, and systolic and diastolic blood pressure were higher in the patient group, this difference was not statistically significant (p > 0.05). ADMA (t: 4.532; p < 0.05) and MDA (t: 9.598; p < 0.05) values were found to be higher and GSH (t: −4.717; p < 0.05) values were found to be lower in the patient group compared to the control group. When correlation analysis was performed between the parameters, a significant relationship was found only between GSH values and ADMA values (r: −0.256; p < 0.05). Accordingly, as the patients’ GSH values increased, ADMA values decreased. Conclusions: Increased WBC, ADMA, and MDA levels, and decreased GSH levels in PV patients reveal the critical role of oxidative stress and inflammation in the disease process. Evaluation of these biomarkers may contribute to the identification of new targets for the treatment of PV and the development of more effective management strategies.

BackgroundAcne vulgaris is a chronic inflammatory disease with multifactorial etiology. Studies on the pathogenesis of acne are still important. Recently, various studies have been conducted on the significance of genetics in the pathogenesis of acne. Blood group is transferred genetically and could affect the development, progress, and severity of certain diseases. AimIn the current study, the correlation between the severity of acne vulgaris and ABO blood groups was investigated. Materials and MethodsA total of 380 patients (263 mild and 117 severe acne vulgaris patients) and 1000 healthy individuals were included in the study. Severity of acne vulgaris patients and healthy controls was determined based on the blood group and Rh factor data obtained retrospectively from the patient files in the hospital automation system. ResultsIn the study, the rate of females was significantly higher in the acne vulgaris group (X-2:154.908; p:0.000). The mean age of the patient was significantly lower when compared to the controls (t:37.127; p:0.0001). The mean age of the patients with severe acne was significantly lower when compared to those with mild acne. When compared to the control group, the incidence of severe acne was higher in those A blood type when compared to the patients with mild acne, while the incidence of mild acne was higher in other blood groups when compared to the control (X-2:17.756; p:0.007). No significant difference was determined between the Rh blood groups of the patients with mild, severe acne and the control group (X-2:0.812; p:0.666). ConclusionThe results revealed a significant correlation between acne severity and ABO blood groups. Future studies that would be conducted with larger samples in different centers could confirm the current study findings.

Background: Artificial intelligence holds significant potential in dermatology. Objectives: This study aimed to explore the potential and limitations of artificial intelligence applications in dermatology education by evaluating ChatGPT's performance on questions from the dermatology residency exam. Method: In this study, the dermatology residency exam results for ChatGPT versions 3.5 and 4.0 were compared with those of resident doctors across various seniority levels. Dermatology resident doctors were categorized into four seniority levels based on their education, and a total of 100 questions—25 multiple‐choice questions for each seniority level—were included in the exam. The same questions were also administered to ChatGPT versions 3.5 and 4.0, and the scores were analyzed statistically. Results: ChatGPT 3.5 performed poorly, especially when compared to senior residents. Second ( p = 0.038), third ( p = 0.041), and fourth‐year senior resident physicians ( p = 0.020) scored significantly higher than ChatGPT 3.5. ChatGPT 4.0 showed similar performance compared to first‐ and third‐year senior resident physicians, but performed worse in comparison to second ( p = 0.037) and fourth‐year senior resident physicians ( p = 0.029). Both versions scored lower as seniority and exam difficulty increased. ChatGPT 3.5 passed the first and second‐year exams but failed the third and fourth‐year exams. ChatGPT 4.0 passed the first, second, and third‐year exams but failed the fourth‐year exam. These findings suggest that ChatGPT was not on par with senior resident physicians, particularly on topics requiring advanced knowledge; however, version 4.0 proved to be more effective than version 3.5. Conclusion: In the future, as ChatGPT's language support and knowledge of medicine improve, it can be used more effectively in educational processes.

ObjectiveThe present study was intended to compare the body image, self-esteem, temperament and character traits of a group of patients who applied for aesthetic rhinoplasty with healthy controls subjects.MethodsThirty patients who applied the Plastic, Reconstructive and Aesthetic Surgery Clinic at the Fırat University Hospital for aesthetic surgery were included in the present study. In addition, thirty healthy individuals who met the study criteria and were matched the patient group by age and gender were included in the study as the healthy control group. Temperament and Character Inventory (TCI), body image (BI) scale, The Rosenberg Self-Esteem Scale (RSES), and sociodemographic data form were applied to patient and control groups.ResultsThe patients with aesthetic rhinoplasty had higher body image (BI) scores compared to the control group (t = 2.828, p = .006), and had higher novelty seeking (NS) (p = .038) and lower harm avoidance (HA) scores for temperament dimensions. The outcomes of the c...

Scabies on YouTube: The Quality, Accuracy, and Reliability of the Videos - Turkish Journal of Dermatology

Introduction: Anogenital warts (AGWs) are proliferative lesions mainly presenting in the anal, genital, and perianal regions. They are one of the most prevalent sexually transmitted infections globally.Methods: The study included patients that presented at the Dermatology Clinic of Health Sciences, University Elazig, Fethi Sekin City Hospital between January 2019 and December 2022 and were diagnosed with AGWs. Patients that presented with this diagnosis and were screened for other sexually transmitted infections (HBsAg, anti-HBs, anti-HCV, anti-HIV, VDRL, and TPHA) were identified. Epidemiological and demographic patient data and the results of serological tests for other sexually transmitted infections in the last 4 years were analyzed. The patient data and examination results were collected retrospectively based on the hospital automated patient records.Results: AGW incidence was significantly higher in males. The mean patient age was 32, and the mean female patient age was lower than that of males. It was observed that the number of patients that were followed up with an AGW diagnosis increased significantly during the last 4 years (p < 0.05). The study detected 2.2% HBsAg, 0.6% TPHA, 0.3% VDRL, 0.5% anti-HCV, and 56.5% anti-HBs positivity. No anti-HIV-positive patients were identified. None of the patients had more than one sexually transmitted infection on serology testing.Conclusions: Although the serological findings were higher when compared to certain studies and quite low when compared to others, it would be beneficial to evaluate all patients with AGWs for other sexually transmitted infections.