The relationship between the methylenetetrahydrofolate reductase (MTHFR) A1298C polymorphism and the susceptibility of diabetes remains inclusive or controversial. For better understanding of the influence of MTHFR A1298C polymorphism on diabetes risk, we performed this meta-analysis. All related articles were identified through a search of PubMed, Embase, Chinese Biomedical Literature Database (CBM, Chinese), China National Knowledge Infrastructure (CNKI), and Wangfang Database (Chinese). The relationship between the MTHFR A1298C polymorphism and diabetes susceptibility was conducted by odds ratios (ORs) and 95% confidence intervals. Total of six studies with 897 cases and 852 controls were included in our meta-analysis. Overall, the significance associated was found between MTHFR A1298C polymorphism and the susceptibility of diabetes under recessive model (CC vs. OR=1.70, 95% CI=1.18-2.45, p=0.004). On the subgroup analysis according to ethnicity, the results indicated that MTHFR A1298C polymorphism has a significant association with diabetes in Asian population under dominant model (CC/AC vs. AA: OR=1.31, 95% CI=1.003-1.72, p=0.047). However, there was no association found between MTHFR A1298C polymorphism and diabetes susceptibility in Caucasians. The results indicated that the MTHFR A1298C polymorphism is a dangerous factor for diabetes, especially for Asians.

The association between vascular endothelial growth factor (VEGF) +936C/T polymorphism and breast cancer risk has been widely reported, but results were inconsistent. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. Eligible articles were identified through search of databases including PubMed, Embase, and Chinese Biomedical Literature Database (CBM). The association between the VEGF +936C/T polymorphism and breast cancer risk was conducted by odds ratios (ORs) and 95 % confidence intervals (95 % CIs). Finally, a total of 13 studies with 6,879 cases and 7,219 controls were included in our meta-analysis. Overall, a significant association was found between VEGF +936C/T polymorphisms and the risk of breast cancer in overall populations under five models (T vs. C: OR = 0.83, 95 % CI = 0.73–0.94, P = 0.002; TT vs. CC: OR = 0.74, 95 % CI = 0.61–0.91, P = 0.004, Fig. 1a ; TC vs. CC: OR = 0.83, 95 % CI = 0.71–0.96, P = 0.014; TT vs. CC/CT: OR = 0.77, 95 % CI = 0.62–0.94, P = 0.010; TT/TC vs. CC: OR = 0.82, 95 % CI = 0.72–0.95, P = 0.006). In the subgroup analysis by ethnicity, there were also significant associations found between VEGF +936C/T polymorphism and breast cancer risk in Asians and Caucasians. In conclusion, the results of our meta-analysis suggest that the VEGF +936C/T polymorphism is significantly associated with breast cancer development and the VEGF 936T allele carriers may be associated with decreased breast cancer risk.

To realize the real-time monitoring and evaluation of the bearing state such as force and deformation, and to meet the intelligent development needs of “self-sensing and self-evaluation” of engineering structures, this paper carried out a finite element simulation of the mechanical properties of spherical bearings and developed a new type of spherical force-measuring bearing based on the button type microsensors through the integration of structural monitoring technology. The simulation results show that the von Mises stress of the spherical bearing is mainly concentrated in the annular region where the edge of the spherical crown is located, and the magnitude of the force value decreases from the edge to the center gradually. The performance characteristics of spherical force-measuring bearings based on the button-type microsensor were studied by combining finite element simulation and experiments. The research results show that the sensitivity of this type of sensor is stable, and the growth trend of the measurement data is ideal with small dispersion, which is in line with the distribution law of the bearing internal force. The temperature loading test was carried out to study the effect of temperature on the bearing measurement accuracy. The fixed force value obtains the relationship between strain and temperature, and the minimum value method is proposed to calculate the temperature compensation coefficient and temperature compensation equation by fitting the slope of a straight line to improve the measurement accuracy of the sensor. Therefore, the research results have good value for engineering applications.

The relationship between the X-ray repair cross-complementing group 3 (XRCC3) Thr241Met (rs861539) polymorphism and the risk of leukemia remains inclusive or controversial. For a better understanding of the effect of XRCC3 Thr241Met (rs861539) polymorphism on leukemia risk, we performed a meta-analysis. All eligible studies were identified through a search of PubMed, Excerpta Medica Database (Embase) and the Chinese Biomedical Literature Database (CBM) up to August 2013. The association between the XRCC3 Thr241Met (rs861539) polymorphism and leukemia risk was analyzed by means of odds ratios (ORs) and 95% confidence intervals (CI). Ultimately, seven studies with 1070 cases and 1850 controls were included in the meta-analysis. There was no association between Thr241Met polymorphism and leukemia risk in any of the five models in the overall populations (T vs. C: OR = 1.43, 95% CI = 0.95-2.13, p = 0.086; TT vs. CC: OR = 1.71, 95% CI = 0.88-3.33, p = 0.112; TC vs. CC: OR = 1.35, 95% CI = 0.96-1.91, p = 0.089; TT vs. OR = 1.59, 95% CI = 0.87-2.89, p = 0.132; TT/TC vs. CC: OR = 1.37, 95% CI = 0.98-1.94, p = 0.070). In subgroup analysis according to ethnicity, a significant association was found between XRCC3 Thr241Met (rs861539) polymorphism and leukemia risk in Asian but not in Caucasian or mixed populations. In conclusion, the results suggest no association between XRCC3 Thr241Met (rs861539) polymorphism and leukemia risk in the overall populations but a significant association between XRCC3 Thr241Met (rs861539) polymorphism and leukemia risk in the Asian population. Considering the limited sample size and ethnicities included in the meta-analysis, further large-scale, well-designed studies are needed to confirm our results.

In this study, a tubular spot-welded grating sensor composed of a stainless-steel tube fixed to a substrate surface by welding is developed, and the tube is filled with high-performance epoxy resin components after the grating sensor is passed through it. A smart steel strand cable is created by spot welding steel strands using portable spot-welding equipment. This method generates a small current during spot welding, with a voltage of only 3 V to 5 V, and does not damage the internal structure of the steel strand. An equation related to the temperature, tension force, and wavelength fluctuation is presented in this article. A method with a transverse temperature coordinate and a longitudinal wavelength coordinate is used. A formula for the standard temperature calibration of the force values and a procedure for temperature adjustment of the force values are presented. The correlation coefficient between the stress on the steel strand and the wavelength of the tubular spot-welded grating sensor is as high as 0.999 according to static tensile testing, demonstrating good repeatability. The temperature adjustment coefficient for varying temperatures is 0.0264 nm/°C, and the test error is essentially limited to 3.0% F.S. When subjected to a 120 h relaxation test, the steel strand with the tubular spot-welded grating sensor exhibits a relaxation rate of 4.44%. The force value obtained after the relaxation test is 1.2% off from the standard load. A tubular spot-welded grating sensor is welded onto a steel strand within a cable sealing cylinder to create an extruded anchor epoxy-coated steel strand cable. The measured cable force is compared with the standard load. The maximum error is 0.5% F.S. The discrepancy between the measured cable force and the acceleration sensor value is 1.5% in one instance involving an arch bridge employing six smart suspension cables to detect cable forces onsite. The findings provide theoretical and engineering references for smart cables and demonstrate the high accuracy, dependability, and fixation performance of the tubular spot-welded grating sensor smart cable.