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Coronavirus disease (COVID-19) was first observed in Wuhan, Hubei Province (China) in December 2019, resulting in an acute respiratory syndrome. Only later was COVID-19 considered a public health emergency of international concern and, on 11 March 2020, the WHO classified it as pandemic. Despite being a respiratory virus, the clinical manifestations are also characterized by cardiological involvement, especially in patients suffering from previous comorbidities such as hypertension and diabetes mellitus, its complications being potentially serious or fatal. Despite the efforts made by the scientific community to identify pathophysiological mechanisms, they still remain unclear. A fundamental role is played by the angiotensin 2 converting enzyme, known for its effects at the cardiovascular level and for its involvement in COVID-19 pathogenesis. The goal of this paper was to highlight the mechanisms and knowledge related to cardiovascular involvement during the first pandemic phase, as well as to emphasize the main cardiological complications in infected patients.
Andrea Canalella; Ermanno Vitale; Francesca Vella; Paola Senia; Emanuele Cannizzaro; Caterina Ledda; Venerando Rapisarda. How the Heart Was Involved in COVID-19 during the First Pandemic Phase: A Review. Epidemiologia 2021, 2, 124 -139.
AMA StyleAndrea Canalella, Ermanno Vitale, Francesca Vella, Paola Senia, Emanuele Cannizzaro, Caterina Ledda, Venerando Rapisarda. How the Heart Was Involved in COVID-19 during the First Pandemic Phase: A Review. Epidemiologia. 2021; 2 (1):124-139.
Chicago/Turabian StyleAndrea Canalella; Ermanno Vitale; Francesca Vella; Paola Senia; Emanuele Cannizzaro; Caterina Ledda; Venerando Rapisarda. 2021. "How the Heart Was Involved in COVID-19 during the First Pandemic Phase: A Review." Epidemiologia 2, no. 1: 124-139.
Straining is an attenuated form of mobbing, in which the continuity of vexatious actions is not driven by a discriminatory intent. With the objective of testing the possible moderating role of personality in the relationship between perceptions about straining at work and individual consequences, a correlational design research involved 374 healthcare workers (HCWs) from two Italian hospitals. The following questionnaires were administered: (1) Short Negative Acts Questionnaire (S-NAQ), to assess discriminative actions at work); (2) the Italian version of the Big Five Inventory (BFI-10 scale), to assess personality factors; (3) Occupational Stress Indicator (OSI), to measure psychological and physical health. Regression analysis and Structural Equation Models (SEM) were computed in order to test the relationships between variables. Perceived straining showed significant correlations with both psychological and physical health. Conscientiousness was inversely proportional to work-related bullying (WB), as agreeableness was to personal bullying (PB). Emotional stability was negatively correlated with all the three component scales of S-NAQ: WB, PB, and social bullying. The results seem to confirm that straining perceptions especially elicit, through emotional stability, psychological consequences. As regards the role of emotional stability in risk perceptions, it seems management has to pay thorough attention to personal factors in organizational perceptions and to straining actions.
Tiziana Ramaci; Massimiliano Barattucci; Francesca Vella; Paola Senia; Emanuele Cannizzaro; Alessandro Scorciapino; Caterina Ledda; Andrea De Giorgio; Venerando Rapisarda. Straining at Work and Its Relationship with Personality Profiles and Individual Consequences in Healthcare Workers (HCWs). International Journal of Environmental Research and Public Health 2020, 17, 610 .
AMA StyleTiziana Ramaci, Massimiliano Barattucci, Francesca Vella, Paola Senia, Emanuele Cannizzaro, Alessandro Scorciapino, Caterina Ledda, Andrea De Giorgio, Venerando Rapisarda. Straining at Work and Its Relationship with Personality Profiles and Individual Consequences in Healthcare Workers (HCWs). International Journal of Environmental Research and Public Health. 2020; 17 (2):610.
Chicago/Turabian StyleTiziana Ramaci; Massimiliano Barattucci; Francesca Vella; Paola Senia; Emanuele Cannizzaro; Alessandro Scorciapino; Caterina Ledda; Andrea De Giorgio; Venerando Rapisarda. 2020. "Straining at Work and Its Relationship with Personality Profiles and Individual Consequences in Healthcare Workers (HCWs)." International Journal of Environmental Research and Public Health 17, no. 2: 610.
Malignant pleural mesothelioma (MM) is a highly aggressive tumor characterized by a poor prognosis. Although its carcinogenesis mechanism has not been strictly understood, about 80% of MM can be attributed to occupational and/or environmental exposure to asbestos fibers. The identification of non-invasive molecular markers for an early diagnosis of MM has been the subject of several studies aimed at diagnosing the disease at an early stage. The most studied biomarker is mesothelin, characterized by a good specificity, but it has low sensitivity, especially for non-epithelioid MM. Other protein markers are Fibulin-3 and osteopontin which have not, however, showed a superior diagnostic performance. Recently, interesting results have been reported for the HMGB1 protein in a small but limited series. An increase in channel proteins involved in water transport, aquaporins, have been identified as positive prognostic factors in MM, high levels of expression of aquaporins in tumor cells predict an increase in survival. MicroRNAs and protein panels are among the new indicators of interest. None of the markers available today are sufficiently reliable to be used in the surveillance of subjects exposed to asbestos or in the early detection of MM. Our aim is to give a detailed account of biomarkers available for MM.
Caterina Ledda; Paola Senia; Venerando Rapisarda. Biomarkers for Early Diagnosis and Prognosis of Malignant Pleural Mesothelioma: The Quest Goes on. Cancers 2018, 10, 203 .
AMA StyleCaterina Ledda, Paola Senia, Venerando Rapisarda. Biomarkers for Early Diagnosis and Prognosis of Malignant Pleural Mesothelioma: The Quest Goes on. Cancers. 2018; 10 (6):203.
Chicago/Turabian StyleCaterina Ledda; Paola Senia; Venerando Rapisarda. 2018. "Biomarkers for Early Diagnosis and Prognosis of Malignant Pleural Mesothelioma: The Quest Goes on." Cancers 10, no. 6: 203.