Background/Objectives: Adenomyosis (AM) is a hormone-dependent gynecological disorder that negatively impacts the quality of life and fertility of reproductive-age women. This study aimed to evaluate the effectiveness of herbal medicine (HM) as a post-treatment strategy following high-intensity focused ultrasound (HIFU) therapy. Methods: English, Chinese, and Korean databases were systematically searched up to 24 March 2025. Eligible randomized controlled trials (RCTs) compared HM administration after HIFU therapy with HIFU therapy alone. Statistical analyses included mean difference (MD), standardized mean difference (SMD), and risk ratio (RR) with 95% confidence intervals (CIs). Evidence quality was assessed using GRADE approach. The protocol was registered with INPLASY (No.: INPLASY202530088). Results: Fourteen RCTs involving 1259 patients were included in the review. HM administration after HIFU therapy showed superior efficacy over HIFU therapy alone in reducing uterine volume (MD = −11.84, 95% CI: −13.74 to −9.95; p < 0.00001), adenomyotic lesion volume (MD = −2.86, 95% CI: −3.29 to −2.43; p < 0.00001), serum CA125 levels (SMD = −1.49, 95% CI: −2.41 to −0.58; p < 0.00001), serum estradiol (E2) levels (SMD = −1.28, 95% CI: −1.54 to −1.03; p < 0.0001), and improvements in dysmenorrhea (MD = −0.54, 95% CI: −1.06 to −0.02; p < 0.00001) Conclusions: HM may be an effective and safe adjunct to HIFU for managing AM. However, further high-quality RCTs with long-term follow-up are needed to validate these findings.

Background/Objectives: Pertussis-like syndrome (PLS) presents symptoms similar to whooping cough but without Bordetella pertussis detection. This study assessed the efficacy and safety of combined treatment herbal and Western medicine (HM and WM, respectively) for PLS. Methods: Eleven English, Chinese, Korean, and Japanese databases were searched until 1 December 2024. Randomized clinical trials (RCTs) that compared HM with WM versus WM alone in children with PLS were included. Independent searches and risk-of-bias analyses were conducted. Random-effects and fixed-effects models were utilized. Dichotomous outcomes are presented as the risk ratio (RR) with 95% confidence interval (CI), and continuous outcomes as either the standard mean difference (SMD) or mean difference (MD) with 95% CI. Results: A total of 23 RCTs (performed in China) with 1938 participants were included. The meta-analysis showed that HM with WM is more effective than WM in improving the total effective rate [n = 1888; RR = 1.20; 95% CI: 1.16–1.24; p < 0.001], reducing the disappearance time of main symptoms (especially spastic cough) [n = 815; MD = −3.31; 95% CI: −3.51–−3.11; p < 0.001], shortening the recovery time of routine blood parameters to the normal range [n = 472; MD = −2.79; 95% CI: −3.06–−2.52; p < 0.001], and decreasing hospitalization duration [n = 703; MD = −2.61; 95% CI: −2.85–−2.38; p < 0.001]. Only mild adverse events were reported, with a lower occurrence rate in HM with WM cohorts than in WM cohorts. The quality of evidence ranged from moderate to very low. Conclusions: HM combined with WM is effective and safe for PLS in children, offering a potential alternative for symptom relief.

INPLASY202560096 Combined Effects of Herbal Medicine and Lifestyle Modification on Childhood Simple Obesity: A Systematic Review and Meta-Analysis Keywords: childhood; simple obesity; lifestyle int…