Background: Alopecia areata (AA) is a recurrent immune‐mediated disorder causing hair loss without any scarring being present. It affects hairs on the head or other parts of the body and can occur at any age and in both genders. It seems that AA is associated with a higher rate of psychological disorders resulting from hair loss and the esthetic and social repercussions of it. Common treatments like corticosteroids do not work for every patient and recent treatment options focusing on the immunologic mechanisms like tofacitinib have shown some promising results. Methods: It's a retrospective study on patients with AA, AT, AU taking oral tofacitinib as a treatment for at least 6 months. Scalp hair loss was assessed before treatment and at each visit using the Severity of Alopecia Tool (SALT) score. Results: Of 97 cases, 69.1% demonstrated over 50% SALT score improvement, with 44.3% having 90% or more decrease in SALT score. Patients who suffered from patchy AA were more responsive compared to patients with AT and AU subtypes and had a greater percent change in SALT score. Tofacitinib was tolerated quite well and no significant adverse events were reported. Conclusions: Tofacitinib should be taken into consideration as an efficacious treatment option for patients with AA, AT and AU.
13 February 2025 in Journal of Cutaneous Pathology
Background and Aims: Although the development of acne is influenced by a range of factors, emerging research suggests that dietary choices may also play a role in acne management. The Mediterranean diet is an antioxidant‐rich, low‐glycemic diet with preventive benefit against a range of chronic illnesses. We aimed to investigate the adherence to Mediterranean diet in acne patients and its association with disease severity. Methods: In this case–control study, 105 patients with acne and 105 control individuals were enrolled and their clinical and demographic characteristics were assessed. A valid Persian version of a 14‐item questionnaire called the Mediterranean diet adherence screener (MEDAS) was used to assess adherence to the Mediterranean diet. Results: We did not find any significant difference regarding adherence to Mediterranean diet between patients and control group ( p value = 0.19). 68.6% of male and 54.3% of female patients had low adherence to the Mediterranean diet. There was no significant difference between diet adherence and most of clinical and demographic characteristics of participants including the type of acne, age of onset, gender, disease duration, treatment type, and diet adherence ( p > 0.05). A statistical correlation was found between BMI and diet adherence, with p < 0.05. Total adherence to the Mediterranean diet among patients was significantly correlated with disease severity ( p value = 0.004). We also found significant correlations between disease severity and consumption of some items in the questionnaire including olive oil, butter, nuts and poultry (P values: 0.014, 0.018, 0.005 and 0.018, respectively). Conclusion: Our results suggest beneficial associations between certain aspects of the Mediterranean diet and milder acne severity. Adherence to this healthy dietary pattern may represent a practical adjuvant approach for acne management.