Amyotrophic lateral sclerosis (ALS) is an adult-onset disease characterized by progressive motor neuron degeneration that results in muscle atrophy, spasticity, hyperreflexia, paralysis, and eventually death.
1 The average patient lifespan ranges from 3 to 5 years after diagnosis.
2 Numerous potential factors may contribute to disease, including genetics,
3 exposure to environmental toxins,
4 and trauma to the central nervous system (CNS),
5,6 but in the sporadic form of ALS, a single cause of disease has yet to be identified. Instead, sporadic ALS may result from multiple factors that each increase disease susceptibility.
7