The aim of the present study was to adjust the frontier executive screen (FES) for the Greek population, to develop normative data, and to investigate its ability to discriminate patients diagnosed with frontotemporal dementia from healthy individuals. The FES was administered to 142 community-dwelling healthy adults (age: M = 65.9, SD = 8.5; education: M = 10.8, SD = 4.3; sex: 59% female) and 32 patients diagnosed with frontotemporal dementia (age: M = 69.3, SD = 8.6; education: M = 11.7, SD = 4.8; sex: 31% female). Correlation and regression analyses were performed to determine the association between the FES scores, demographic, and clinical characteristics. Cronbach’s α coefficient was used to determine internal consistency. Group differences on the FES were examined with independent samples t-test and Mann–Whitney test. Discriminant and ROC analyses were used to determine diagnostic accuracy and to identify the optimal cutoff score for the discrimination between groups. Regression analyses indicated associations between demographic characteristics and FES scores (age: R² = .08; education: R² = .33). Internal consistency was marginally acceptable (α = .69). Patients scored lower than healthy participants on the total FES score (d = 1.91) and its three subscores (verbal fluency: η² = .60; inhibition: η² = .52; working memory: d = 0.90). The results indicated high diagnostic accuracy (94%) and the optimal cutoff score was 7 (91% sensitivity, 78% specificity). The Greek version of the FES is a useful tool for the brief evaluation of executive functions in patients diagnosed with frontotemporal dementia.

Purpose: Language production in semantic dementia (SD) is characterized by a lexical–semantic deficit and largely preserved argument structure and inflection production. This study investigates (a) the effect of argument structure on verb retrieval and (b) the interrelation between inflection marking and verb retrieval in SD. Method: Seven individuals with SD and 7 healthy controls performed 2 sentence elicitation tasks. In Experiment 1, participants described the action taking place in a video. In Experiment 2, they watched the same videos preceded by a phrase prompting the production of past tense. Three verb classes were tested: (a) unergative (e.g., to walk ), (b) unaccusative (e.g., to fall ), and (c) transitive with 1 object (e.g., to read a book ). Results: There was not any quantitative difference among the verb classes in Experiment 1, but error analysis hinted at difficulties related with argument structure complexity. The findings of Experiment 2 suggest no general effect of inflection on verb retrieval; nevertheless, inflection marking impeded the retrieval of verbs with complex argument structure. Large individual variation was established. Conclusions: Argument structure complexity may challenge speakers with SD. Verb retrieval and inflection marking seem to interrelate at the expense of the former. Inflection production may be affected at severe stages of the disease. Supplemental Material: https://doi.org/10.23641/asha.6030779

Background and Objectives: Difficulties in language production and comprehension constitute clinical symptoms characterizing patients diagnosed with Primary Progressive Aphasia (PPA). Thorough assessment of language domains can detect specific deficits commonly observed in different PPA variants, but brief and practical instruments capable of screening for language impairment are lacking. The present study aimed to examine the ability of the Mini Linguistic State Examination (MLSE) to distinguish between healthy individuals and PPA patients, as well as to differentiate among PPA subtypes, within Greek clinical practice. Materials and Methods: Τhe Mini Linguistic State Examination (MLSE), a 15-min detailed examination of different language domains, was administered to a group of clinically diagnosed PPA patients and a group of healthy participants. In addition, PPA patients completed a neuropsychological test battery assessing memory, language, executive, and visuospatial functions. Patterns of patients’ brain perfusion were also explored with single-photon emission computed tomography. Results: Comparisons between PPA patients and healthy controls revealed significant differences across all MLSE domains (all p < 0.001), and receiver operating characteristic analyses demonstrated excellent diagnostic accuracy, with AUC values exceeding 0.90 across language domains and perfect classification for the total MLSE score (AUC = 1.00, p < 0.001). Conclusions: These findings indicate that the MLSE is able to detect distinct patterns of deficits and to provide a comprehensive overview of patients’ linguistic profiles, supporting its clinical utility and diagnostic potential for differentiating PPA variants.