Objective: The purpose of this study is to create dexpanthenol-loaded hydrogel formulations to alter the release patterns and enhance the physicochemical qualities of the market product. Material and Method: To make hydrogel formulations, Carbopol Ultrez was utilized in concentrations of 1%, 1.5%, and 2% (w/w). The active component dexpanthenol was then added to the formulations at a concentration of 5% (w/w). pH, viscosity, texture profile analysis, spreadability, bioadhesion, and in vitro release characteristics were all assessed for the formulations. Result and Discussion: The formulations were found to be suitable for cutaneous application. TPA analysis revealed that the G1 and G1-DXP formulations had the hardness value 10.1851.219 and 30.8541.637 g, respectively. That formulations’ bioadhesion strength has grown because they are more flexible than previous formulations while having low hardness values. As such, it has been observed that the formulations release more than 50% of DXP in three hours while the market preparation was not even reach the 10% drug release. In the in vitro release kinetics study, it was calculated that all formulations fit the Higuchi model. As a result, a more effective drug delivery system has been developed compared to the market preparation. The currently prepared formulations are also promising formulations in terms of their use in treatment.

Wounds are broadly classified into acute and chronic types, with chronic wounds being those that cannot heal within 4 to 12 weeks despite treatment. There is a growing interest in efficient and cost-effective wound healing though the drug delivery of active molecules. Natural compounds such as phytochemicals, as well as synthetic molecules with antimicrobial or anti-inflammatory growth factors, can impact tissue regeneration and prevent wound infections. Nanotechnology-based systems, such as polymeric and inorganic nanoparticles and electrospun nanofibrous matrices loaded with phytochemicals, can enhance the therapeutic efficacy of active molecules through improved bioavailability and targeted delivery. This review summarizes the most current advanced applications combining phytochemicals and nanoformulations with promising wound healing potential. Various nanosystems loaded with phytochemicals have been identified, such as silver nanocarriers, zein-based nanoparticles, and various known polymers, which can be utilized to develop electrospun fibrous structures loaded with phytoremedies. Despite the incorporation of these remedies into traditional medicine for a long time, further clinical studies are essential to determine their pharmacological properties, safety concerns, and therapeutic efficacy.

Background/Objectives: Carbon quantum dots (CQDs) are carbon-based structures with particle sizes ranging from 1 to 10 nm. They can be prepared using various carbon sources, including those doped with heteroatoms. CQDs exhibit unique optoelectronic properties, high photostability, low toxicity, and exceptional biocompatibility. It was aimed to produce CQDs from active pharmaceutical ingredients (APIs). Methods: This study introduces a novel class of CQDs synthesized directly from APIs, which we term “Quantum Drugs” (Q-Drugs). We present several APIs alongside detailed methods for Q-Drug synthesis and characterization. We describe the necessary structural properties for forming Q-Drugs and provide the values for particle size, polydispersity index, and zeta potential that were obtained from various drug molecules. Results: The particle sizes were determined with the size of 7.360 ± 0.030 nm and 10.000 ± 0.022 nm; polydispersity indexes of 10.500 ± 1.230 and 32.610 ± 1.401; and zeta potentials of −3.400 ± 0.054 mV and −40.000 ± 0.142 mV, respectively using different APIs. Conclusions: This study successfully demonstrated the synthesis and characterization of Q-Drugs, a novel class of CQD derived from APIs. The results provide valuable data on the physicochemical properties of these Q-Drugs, paving the way for further investigation into their potential applications.

Inflammation occurring in the wound tissue plays an important role in the wound healing process. This situation can cause undesirable conditions such as pain and swelling in patients. Indomethacin (IM) is one of the most frequently preferred nonsteroidal anti-inflammatory (NSAID) active substances that suppress the inflammatory response. Indomethacin blocks prostaglandin synthesis by inhibiting the cyclooxygenase enzyme and thus helps support the wound healing process. This study includes hydrogel formulations of quantum dots (IMQDs) prepared from the indomethacin active substance for the first time. Characterization studies of the prepared IMQDs were carried out and particle sizes, % polydispersity indexes, and zeta potentials were measured as 8.53±0.096 nm, 19.49±0.550 %, -8.2±0.781 mV, respectively. Quantum yield % was calculated as 56.48%. Hydrogel formulations containing F1 (0.5%), F2 (0.75%), and F3 (1%) containing carbomer at different concentrations and F1-IMQDs, F2-IMQDs and F3-IMQDs containing 2% IMQDs were prepared. The prepared hydrogels' viscosity, pH, mechanical properties, and spreadability were measured. In vitro release studies of all formulations were performed, and it was seen that the gel drug containing IMQDs exhibited a higher release rate than traditional drugs. At the same time, the gel containing IMQDs showed fluorescent properties. Cell culture studies did not show toxicity. In line with the obtained data, the hydrogel formulations containing IMCQDs prepared can be applied to dermal wound healing or anti-inflammatory treatments. This study can be a source for future studies and applications.