Background and Objectives: Hamstring strength deficits are common after ACL reconstruction and may impair stability and increase reinjury risk. Despite structured rehabilitation, early postoperative asymmetries frequently persist. Platelet-rich plasma (PRP) has emerged as a potential biologic adjunct that may enhance tissue healing and facilitate muscle strength recovery. This study aimed to evaluate the efficacy of intra-articular PRP injections on hamstring strength restoration in non-professional athletes undergoing ACLR. Materials and Methods: This retrospective cohort study analyzed 68 non-professional athletes who underwent primary ACLR between 2020 and 2024. Participants followed a standardized, phase-appropriate rehabilitation program and were allocated to either a PRP group (n = 34; five intra-articular PRP injections every 4 weeks starting at week 4 postoperatively) or a control group (n = 34; rehabilitation alone). Data were analyzed with linear mixed-effects models to examine group, time, and group-by-time interactions. Results: Both groups improved over time, but PRP influenced faster hamstring strength recovery and greater symmetry. At 20 weeks, the PRP group achieved higher concentric strength (15.6 ± 4.3 vs. 13.6 ± 3.5; p = 0.040) and markedly reduced asymmetry (isometric: –1.1 vs. 0.6; p < 0.001; concentric: –0.6 vs. 1.9; p < 0.001). Conclusions: The addition of serial PRP injections to a structured rehabilitation protocol after ACLR influenced faster hamstring strength recovery and improved interlimb symmetry compared to rehabilitation alone. These findings suggest that PRP may serve as a potential biologic adjunct to optimize postoperative outcomes and facilitate a safer return to sport in non-professional athletes.

Background/Objectives: This retrospective study aimed to evaluate whether PRP infiltrations improve quadriceps muscle strength recovery following anterior cruciate ligament reconstruction (ACLR), while minimizing the recovery time required to resume daily activities and sports. Numerous studies have explored the use of platelet-rich plasma (PRP) in treating ACL injuries. PRP therapy has demonstrated high efficacy in accelerating ligament healing in animal models. However, clinical trials involving human participants have reported inconsistent results regarding the effects of PRP on ACL reconstruction outcomes. Methods: Between 2020 and 2024, a total of 68 subjects who underwent ACLR were included in the study. Participants were divided into two groups, namely a treatment group that followed a standard rehabilitation protocol and received PRP infiltrations, and a control group that followed the same protocol without PRP treatment. Muscle strength was assessed using the isometric max strength balance (IMSB) test and the concentric max strength balance (CMSB) test, both performed using the Kineo Intelligent Load device (Globus Kineo 7000, Italian Excellence, Rome, Italy). Results: The results of IMSB test showed a significant difference between treatment groups according to a two-way ANOVA test (F(1, 198) = 7.345; p = 0.0073). The PRP-treated group showed significantly higher quadriceps muscle strength at 6 months (34.9 ± 9.6 vs. 30.0 ± 8.2 kg). The CMSB test also showed a significant difference at 6 months (F(1, 198) = 5.976; p = 0.00154), with the PRP-treated group having significantly higher concentric muscle strength (35.5 ± 9.5 vs. 30.7 ± 8.5 kg). Conclusions: These findings suggest that post-ligamentoplasty PRP infiltrations may have beneficial effects on muscle strength recovery. However, further prospective studies with larger sample sizes are necessary to confirm these results.

Background: Recreational mini-football is associated with a high incidence of lower-limb injuries, largely driven by neuromuscular deficits and insufficient exposure to structured preventive training. This study aimed to evaluate the effects of a hybrid injury-prevention program combining the FIFA 11+ protocol with customized neuromuscular interventions on functional performance and injury-related risk factors. Methods: Forty male recreational mini-football players were included in a retrospective analysis of data collected during the routine implementation of a 12-week hybrid preventive training program. Participants were allocated to an intervention group (n = 20) or control group (n = 20) according to routine training practices rather than randomization. The intervention was performed twice weekly. Outcome measures included lower-limb strength (Kineo system), dynamic balance (Y-Balance Test), functional hop performance (Single Hop and Side Hop tests), and agility/change-of-direction ability (Illinois and 505 tests). Results: The intervention group demonstrated significantly greater improvements in lower-limb peak force across all muscle groups (all adjusted p < 0.001), as well as in single-leg hop, side hop, and agility/change-of-direction performance (all adjusted p < 0.001) compared to controls. No significant changes were observed in dynamic balance outcomes. Conclusions: A hybrid neuromuscular training program combining FIFA 11+ with customized exercises was associated with improvements in lower-limb strength, hop performance, and agility/change-of-direction ability in recreational mini-football players. These findings suggest that integrating customized exercises into standardized training programs may enhance functional performance and positively influence modifiable factors associated with injury risk.