Objectives: Depression is a significant and growing global concern with substantial societal impact. College students, being particularly vulnerable to depression, necessitate exploration of physical activity (PA) as a potential mitigating factor. This study aims to examine the relationship between PA and depression in college students. Methods: Studies were identified through systematic searches of PubMed, Embase, Cochrane, Scopus, and Web of Science. The Pearson correlation coefficient was utilized to assess the PA–depression relationship. Heterogeneity was evaluated, and subgroup analyses were performed. Sensitivity analysis via the leave-one-out method was conducted. Quality assessment was assessed using the Joanna Briggs Institute literature quality assessment approach, resulting in the inclusion of 38 high-quality, low-risk studies. Results: A significant negative correlation between PA and depression was found (r = −0.238; 95% CI, −0.307 to −0.173; p < 0.001). Subgroup analyses revealed notable PA–depression correlations post-COVID-19 (r = −0.324; 95% CI, −0.493 to −0.132; p < 0.001), in developing countries (r = −0.202; 95% CI, −0.213 to −0.191; p < 0.001), and in physical education majors (r = −0.390; 95% CI, −0.589 to −0.147; p < 0.001). Moderate PA levels were associated with reduced depression (r = −0.428; 95% CI, −0.708 to −0.031; p = 0.035). Conclusions: This systematic review and meta-analysis suggests that PA is significantly and negatively associated with depression and plays a crucial role in alleviating depression in college students. Various influences, including the pandemic, national development level, student major, and PA intensity, moderate this relationship. Post-pandemic, developing countries, physical education majors, and moderate PA intensity emerged as optimal factors for enhancing the depression-alleviating effects of PA.

Numerous studies have investigated the effects of exercise on post-stroke depression (PSD), yet the findings remain inconclusive. This study aims to evaluate the impact of exercise on depressive symptoms in stroke patients and to identify the most effective exercise protocols for this population. A systematic review of the Embase, PubMed, Cochrane Library, Web of Science, and Scopus databases was conducted, with a search cutoff date of 13 September 2024. Quantitative synthesis was employed to assess the intervention effects, with effect sizes expressed as standardized mean differences (SMDs) and 95% confidence intervals to evaluate the efficacy of exercise in alleviating PSD. A total of 24 studies met the inclusion criteria. The results indicated that exercise significantly alleviated depressive symptoms in stroke patients (SMD = −0.18; p = 0.007). Specifically, multicomponent training emerged as the most effective intervention for reducing depression (SMD = −0.24; p = 0.008). Additionally, exercise programs with a duration of ≥12 weeks (SMD, −0.17; p = 0.04), ≥3 sessions per week (SMD, −0.20; p = 0.02), <60 min per session (SMD, −0.19; p = 0.05), and <180 min per week (SMD, −0.27; p = 0.02) were found to be the most effective in alleviating PSD. Exercise represents an effective strategy for managing PSD, with multicomponent training potentially serving as the optimal intervention. These findings provide evidence for clinicians, recommending that stroke patients engage in exercise at least three times weekly, with individual sessions not exceeding 60 min. By increasing the frequency of exercise, the cumulative weekly time should ideally remain below 180 min for optimal outcomes.

This study aimed to investigate the effects of exercise on aerobic capacity and quality of life (QOL) in heart failure (HF) patients and to identify the optimal exercise prescription for improving aerobic capacity and QOL. A comprehensive search was conducted in Embase, PubMed, Cochrane Library, Web of Science, and Scopus covering data published up to 9 October 2024. The Population, Intervention, Comparison, Outcome (PICO) framework was used to define the inclusion. (a) Population: patients with HF; (b) Intervention: randomized controlled trials (RCTs) with subjects randomly assigned to either the intervention or control group; (c) Comparison: studies that measured peak oxygen uptake (VO₂peak), maximal oxygen uptake (VO₂max), or the Minnesota Living with Heart Failure Questionnaire (MLHFQ) at baseline and compared results post-intervention; (d) Outcome: the primary outcomes were aerobic capacity and QOL. The Physiotherapy Evidence Database (PEDro) scale and the Cochrane Risk of Bias 2 (RoB-2) tool were used to assess the quality of the included studies. Weighted mean difference (WMD), standardized mean difference (SMD), and 95% confidence interval were used to pool data. A total of 47 studies met the inclusion criteria. Exercise significantly improved aerobic capacity (WMD, 2.85, p < 0.00001) and QOL (SMD, −0.79, p < 0.00001) in HF patients. Subgroup analyses indicated that combined exercise, session duration ≥ 60 min, ≥3 sessions per week, ≥180 min per week, and supervised exercise showed more significant improvements in aerobic capacity and QOL. Additionally, exercise had greater benefits in middle-aged patients. To improve aerobic capacity and QOL, the optimal exercise prescription for HF patients involves engaging in supervised combined exercise at least three times per week, with each session lasting at least 60 min, to achieve a total weekly duration of 180 min. These recommendations are particularly relevant for middle-aged patients, who may experience greater benefits from exercise interventions. The protocol has been registered on PROSPERO with the registration number CRD420250632915.