This study aimed to assess perceived stress levels in individuals with inflammatory bowel disease (IBD) and explore their associations with multidimensional fatigue and sexual quality of life. A total of 252 patients diagnosed with IBD who visited the gastroenterology department of a major hospital in AnHui Province between March 2022 and June 2023 were included. Data were collected using a general information questionnaire, the Chinese Perceived Stress Scale (CPSS), the Arizona Sexual Experience Scale (ASEX), and the Multidimensional Fatigue Inventory (MFI-20). Participants reported a mean perceived stress score of 39.88 ± 7.92, a multidimensional fatigue score of 52.66 ± 13.34, and a sexual quality of life score of 15.98 ± 4.17. Significant positive correlations were observed between perceived stress, sexual quality of life, and multidimensional fatigue (r = 0.402 and 0.643, respectively; both P < 0.001). Bootstrap analysis revealed that multidimensional fatigue significantly mediated the relationship between sexual quality of life and perceived stress, accounting for 61.8% of the total effect. These findings highlight the importance of timely interventions to reduce perceived stress in patients with IBD. Particular attention should be given to improving sexual quality of life and managing fatigue. Clinicians are encouraged to adopt personalized cognitive strategies to alleviate stress and enhance psychological well-being.

Background This study aimed to identify potential financial toxicity profiles among Chinese patients with inflammatory bowel disease (IBD) and to explore the factors associated with different profiles. Methods Patients with IBD who attended a tertiary Class A hospital in Anhui Province between October 2022 and January 2024 were recruited through convenience sampling. Data were collected using a general information questionnaire, the Comprehensive Score for Financial Toxicity, and the Chinese version of the Perceived Social Support Scale. Latent profile analysis and multivariate logistic regression were conducted to classify financial toxicity profiles and examine their determinants. Results Three distinct profiles of financial toxicity were identified: a “high financial toxicity group” (46.03%), a “moderate financial toxicity group” (48.41%), and a “low financial toxicity group” (5.56%). Multivariate logistic regression indicated that lower levels of social support and an annual household income below 30,000 CNY were significant predictors of financial toxicity ( P < 0.05). Conclusions Considerable heterogeneity exists in financial toxicity among patients with IBD. Tailored interventions based on patients’ financial toxicity profiles may help healthcare professionals mitigate financial burden and improve patient outcomes.