Background: Shirakiopsis indica (Willd.) (Family: Euphorbiaceae), a mangrove species found in the Asian region, is a popular folkloric plant. Locally, the plant is traditionally used to treat various types of ailments, especially for pain relief. Therefore, the current study investigates the neuropharmacological, antipyretic, thrombolytic, and anthelmintic properties of the S. indica fruit methanolic extract (SIF-ME). Methods: The neuropharmacological activity was evaluated using several bioactive assays, and the antipyretic effect was investigated using the yeast-induced pyrexia method, both in Swiss albino mice models. Human blood clot lysis was employed to assess thrombolytic activity, while in vitro anthelmintic characteristics were tested on Tubifex tubifex. Insights into phytochemicals from SIF-ME have also been reported from a literature review, which were further subjected to molecular docking, pass prediction, and ADME/T analysis and validated the wet-lab outcomes. Results: In the elevated plus maze test, SIF-ME at 400 mg/kg demonstrated significant anxiolytic effects (200.16 ± 1.76 s in the open arms, p < 0.001). SIF-ME-treated mice exhibited increased head dipping behavior and spent a longer time in the light box, confirming strong anxiolytic activity in the hole board and light–dark box tests, respectively. It (400 mg/kg) also significantly reduced depressive behavior during forced swimming and tail suspension tests (98.2 ± 3.83 s and 126.33 ± 1.20 s, respectively). The extract induced strong locomotor activity, causing mice’s mobility to gradually decrease over time in the open field and hole cross tests. The antipyretic effect of SIF-ME (400 mg/kg) was minimal using the yeast-induced pyrexia method, while it (100 μg/mL) killed T. tubifex in 69.33 ± 2.51 min, indicating a substantial anthelmintic action. SIF-ME significantly reduced blood clots by 67.74% (p < 0.001), compared to the control group’s 5.56%. The above findings have also been predicted by in silico molecular docking studies. According to the molecular docking studies, the extract’s constituents have binding affinities ranging from 0 to −10.2 kcal/mol for a variety of human target receptors, indicating possible pharmacological activity. Conclusions: These findings indicate that SIF-ME could serve as a promising natural source of compounds with neuropharmacological, anthelmintic, thrombolytic, and antipyretic properties.

Background: Figs (Ficus carica L.), widely valued in Asia and the Middle East, are recognized for their rich nutritional profile and medicinal properties, including potential anti-cancer and cardiovascular benefits. Both fresh and dried figs are abundant in fiber, trace minerals, antioxidant polyphenols, proteins, sugars, organic acids, and volatile compounds. This study aimed to evaluate the quality of fig jams prepared with three different sweeteners—white sugar, brown sugar, and honey. Methods: The jams were analyzed for their nutritional composition (fat, protein, fiber, vitamin C, carbohydrates, and total solids), chemical properties (titratable acidity and pH), bioactive compounds (total phenolic, flavonoid, and anthocyanin contents), and microbial safety (total viable count, yeast, and mold counts). Results: The findings revealed that honey fig jam had the highest acidity (0.048 ± 0.001), fiber (2.38 ± 0.002%), protein (5.95 ± 0.05%), and vitamin C (8.00 ± 0.1 mg/100g) content. White sugar fig jam exhibited the lowest moisture content (36.28 ± 0.28%) and ash percentage (0.70 ± 0.05%). The total soluble solids (TSS) were highest in brown sugar fig jam (67 ± 1.00%) and slightly lower in white sugar and honey fig jams (66 ± 1.00%). Significant differences (p < 0.05) in phytochemical compounds were observed among the samples. Conclusion: These results highlight the influence of sweeteners on the quality attributes of fig jam, with brown sugar emerging as a favorable option for optimizing both nutritional value, chemical quality and sensory properties. This study provides valuable insights for the development of fig-based products, contributing to the growing demand for functional foods.

Background: This study addresses the critical issue of malnutrition among under-five children in Moheshkhali, Cox's Bazar, Bangladesh. Despite the alarming rates of stunting, wasting, and underweight in this region, there is a significant lack of localized data on socioeconomic factors, IYCF practices, and overall health status. Understanding these variables is essential for developing effective interventions. Methods: The research involved a cross-sectional study design, where anthropometric measurements were conducted to assess the nutritional status of children aged 6 to 59 months. Maternal education, age, and Body Mass Index (BMI) were also evaluated to explore their impacts on child nutrition. Data were analyzed using standard statistical methods to draw correlations and identify trends. Results: The findings revealed a high prevalence of malnutrition among under-five children, with notable gender disparities in stunting and underweight. The analysis indicated a strong relationship between maternal health indicators—particularly BMI—and child nutritional outcomes. Moreover, inadequate adherence to IYCF practices was observed, with many mothers failing to implement optimal breastfeeding and complementary feeding strategies. Conclusion: The study underscores the urgent need for targeted interventions aimed at improving maternal education and IYCF practices in Moheshkhali. A multi-sectoral approach involving government and non-government organizations is essential to address the malnutrition crisis effectively. Investing in preventive measures and promoting healthy feeding practices are crucial for ensuring the well-being of both mothers and their children.