Amphiphilic diblock copolymers comprising polyethylene glycol (PEG) and 1-vinyl imidazole (VIM) were synthesized using reversible addition–fragmentation chain transfer (RAFT) polymerization. The study focused on the synthesis of well-defined nanostructures with tunable composition and their functional modification for biomedical applications. The successful polymerization of PEG-b-PVIM diblock copolymers was confirmed via ¹H NMR spectroscopy, and their molecular weights were analyzed using gel permeation chromatography (GPC). The copolymers exhibited pH-responsive behavior, with effective pK values of approximately 4.2. To facilitate radiolabeling and in vivo tracking, a post-polymerization modification enabled the conjugation of a 1,4,7-Triazacyclononane-1,4,7-triacetic acid (NOTA) chelator via aminolysis. The final conjugates were purified and characterized, confirming successful functionalization. These findings highlight the potential of PEG_x-b-PVIM_y diblock copolymers for biomedical applications.

The advent of the Sustainable Development Goals (SDGs) by the United Nations (UN) in 2015 has redefined global development priorities, emphasizing the intertwined objectives of eradicating poverty, ensuring health, and promoting environmental sustainability. This review critically examines the role of radiopharmaceuticals and nuclear medicine in advancing these goals, particularly SDG 3 (Good Health and Well-being). Radiopharmaceuticals and nuclear medicine provide unparalleled precision in diagnosing and treating various diseases, including cancer, cardiovascular, and neurological disorders, thus enhancing global health outcomes and reducing healthcare disparities. Despite their transformative potential, integrating these technologies into global health systems faces significant challenges. Key among these are issues of accessibility and affordability, especially in low- and middle-income countries and environmental sustainability concerns related to the production and disposal of radioactive materials. Addressing these challenges is imperative to align with SDG 12 and SDG 13. Future directions for the field must prioritize innovation, sustainability, and international collaboration. This includes the development of novel radiopharmaceuticals with improved diagnostic and therapeutic efficacy, adopting environmentally friendly synthesis methods, and harmonising regulatory frameworks to facilitate global accessibility. Strengthening global partnerships and enhancing capacity building through targeted educational initiatives are essential to bridge the gap between high-income and low-income regions. In conclusion, radiopharmaceuticals and nuclear medicine are poised to be critical components in achieving the UN' SDGs. These technologies can significantly impact global health, foster socio-economic growth, and contribute to a sustainable and equitable future through concerted efforts in innovation, sustainable practices, and international cooperation.

Koncept farmaceutick? p??e (FP) existuje jako profesn? filozofie ji? v?ce ne? 30 let, nicm?n? po dlouhou dobu bylo pro jeho za?len?n? do b?n? praxe poskytov?n? zdravotn? p??e u?in?no jen m?lo. Pandemie COVID-19 a s n? spojen? zv??en? p??liv p... Koncept farmaceutick? p??e (FP) existuje jako profesn? filozofie ji? v?ce ne? 30 let, nicm?n? po dlouhou dobu bylo pro jeho za?len?n? do b?n? praxe poskytov?n? zdravotn? p??e u?in?no jen m?lo. Pandemie COVID-19 a s n? spojen? zv??en? p??liv p...