A glomus tumor is a benign vascular tumor derived from the modified smooth muscle cells of the glomus body. The lesions develop as small blue-red nodules that are usually located in the deep dermis or subcutis of the upper or lower extremity. The single most common site is the subungual region of the finger, but other common sites include the palm, wrist, forearm and foot. In the present study, we report the case of a 45-year‑old patient diagnosed with extradigital glomus tumor of subcutaneous tissue of elbow. Histopathological examination revealed that the tumor was a well-circumscribed nodule with focal invagination of tumor cells into the adjacent upper dermis. The tumor was composed of solid sheets of cells interrupted by vessels of varying size. Immunohistochemically, the tumor cells were reactive for smooth muscle actin (SMA) and vimentin (VMT). The majority of glomus tumors may be treated adequately by the correct diagnosis and simple excision. However, extradigital glomus tumors are occasionally difficult to diagnose owing to their non-specific clinical characteristics, including unusual sites and symptoms which vary compared with those of classical glomus tumors. Therefore, it is crucial to include glomus tumors in a differential diagnosis of patients with extradigital lesions.

The acidic tumor environment has emerged as a crucial factor influencing the metastatic potential of cancer. We investigated the effect of an acidic environment on the acquisition of metastatic properties in MCF7 breast cancer cells and explored the inhibitory effects of gallic acid. Prolonged exposure to acidic culture conditions (over 12 weeks at pH 6.4) induced the acquisition of migratory and invasive properties in MCF7 cells, accompanied by increased expression of Matrix Metalloproteinase 2 and 9 (MMP2 and MMP9, respectively), together with alterations in E-cadherin, vimentin, and epithelial-to-mesenchymal transition markers. Gallic acid effectively inhibited the survival of acidity-adapted MCF7 (MCF7-6.4/12w) cells at high concentrations (>30 μM) and reduced metastatic characteristics induced by acidic conditions at low concentration ranges (5–20 μM). Moreover, gallic acid suppressed the PI3K/Akt pathway and the nuclear accumulation of β-catenin, which were elevated in MCF7-6.4/12w cells. These findings highlight the potential of gallic acid as a promising therapeutic agent for metastatic traits in breast cancer cells under acidic conditions.

Nodular hyperplasia (nodular or multinodular goiter) is the most common form of thyroid disease. These nodules may undergo secondary changes in the form of hemorrhages, calcification and cystic degeneration. However, osseous metaplasia with mature bone formation rarely occurs. The present study reports the cases of three female patients with thyroid nodules diagnosed as nodular hyperplasia with osseous metaplasia and mature bone formation. The patients underwent right lobectomy, near total thyroidectomy and total thyroidectomy, respectively. The clinical course of the patients following resection were unremarkable.

We describe an epidermoid cyst arising from an accessory spleen of the pancreas. A 56-year-old female with iron deficiency anemia presented with dizziness. During the clinical workup, a 2×4 cm-sized mass was incidentally detected in the tail of the pancreas in a computed tomography (CT) scan. Under a clinical diagnosis of pancreatic cystic malignant tumor, a distal pancreatectomy was carried out. Grossly, the lesion was composed of a solid and cystic portion. Microscopic analysis revealed that the solid portion was an intrapancreatic accessory spleen and the cystic portion was an epidermoid cyst. An epidermoid cyst in an intrapancreatic accessory spleen is extremely rare and hence difficult to diagnose pre-operatively. Taking into account the possibility of such a cyst in the differential diagnosis of intrapancreatic cystic lesion is recommended.

Hong R, et al. Korean J Physiol Pharmacol. 2018 Sep;22(5):513-523. https://doi.org/10.4196/kjpp.2018.22.5.513

A 59-year-old man underwent abdominal CT for evaluation of weight loss and generalized weakness. A large mass protruding from the lesser curvature of the stomach suggestive of gastrointestinal stromal tumor was demonstrated. F-FDG PET/CT showed hypermetabolic activity in the gastric mass. Mass excision and wedge resection were performed, and the diagnosis of inflammatory myofibroblastic tumor was confirmed.