Traditional tsunami vulnerability assessments often rely on empirical models and field surveys, which can be time-consuming and have limited accuracy. In this study, we propose a novel approach that integrates high-resolution Unmanned Aerial Vehicle (UAV) photogrammetry with numerical simulation to improve vulnerability assessment efficacy in Ancon Bay, Lima, Peru, by using the Papathoma Tsunami Vulnerability Assessment (PTVA-4) model. For this purpose, a detailed 3D representation of the study area was generated using UAV-based oblique photogrammetry, enabling the extraction of building attributes. Additionally, a high-resolution numerical tsunami simulation was conducted using the TUNAMI-N2 model for a potential worst-case scenario that may affect the Central Peru subduction zone, incorporating topographic and land-use data obtained with UAV-based nadir photogrammetry. The results indicate that the northern region of Ancon Bay exhibits higher relative vulnerability levels due to greater inundation depths and more tsunami-prone building attributes. UAV-based assessments provide a rapid and detailed method for evaluating building vulnerability. These findings indicate that the proposed methodology is a valuable tool for supporting coastal risk planning and disaster preparedness in tsunami-prone areas.