Automated classification of magnetic resonance brain images (MRIs) is a hot topic in the field of medical and biomedical imaging. Various methods have been suggested recently to improve this technology. In this paper, to reduce the complexity involved in the medical images and to ameliorate the classification of MRIs, a novel 3D magnetic resonance (MR) brain image classifier using kernel principal component analysis (KPCA) and support vector machines (SVMs) is proposed. Experiments are carried out using A deep multiple kernel SVM (DMK-SVM) and a regular SVM. An algorithm entitled SVM–KPCA is put forward. Its main task is to classify a brain MRI as a normal brain image or as a pathological brain image. This algorithm, firstly, adopts the discrete wavelet transform technique to extract features from images. Secondly, KPCA is applied to decrease the dimensionality of features. SVM is then applied to the reduced data. A K-fold cross-validation strategy is used to avoid overfitting and to ameliorate the generalization of the SVM–KPCA algorithm. Three databases are used to validate the suggested SVM–KPCA method. Three conclusions are obtained from this work. First, KPCA is highly efficient in increasing the classifier’s performance compared with similar algorithms working on the proposed database. Second, the SVM–KPCA algorithm performs well in differentiating between two classes of medical images. Third, the approach is robust and might be utilized for other MRIs. This proposes a significant role for computer aided diagnosis analysis systems used for clinical practice.

Alzheimer’s disease (AD) is the most prevalent type of dementia. It is linked with a gradual decline in various brain functions, such as memory. Many research efforts are now directed toward non-invasive procedures for early diagnosis because early detection greatly benefits the patient care and treatment outcome. Additional to an accurate diagnosis and reduction of the rate of misdiagnosis; Computer-Aided Design (CAD) systems are built to give definitive diagnosis. This paper presents a novel CAD system to determine stages of AD. Initially, deep learning techniques are utilized to extract features from the AD brain MRIs. Then, the extracted features are reduced using a proposed feature reduction technique named Deep Downsized Kernel Partial Least Squares (DDKPLS). The proposed approach selects a reduced number of samples from the initial information matrix. The samples chosen give rise to a new data matrix further processed by KPLS to deal with the high dimensionality. The reduced feature space is finally classified using ELM. The implementation is named DDKPLS-ELM. Reference tests have been performed on the Kaggle MRI dataset, which exhibit the efficacy of the DDKPLS-based classifier; it achieves accuracy up to 95.4% and an F1 score of 95.1%.

The development of Computer-Aided Design (CAD) and Computer-Aided Manufacturing (CAM) systems in the past decade has led to a remarkable advance in biomedical applications and devices. Particularly, CAM and CAD systems are employed in medical engineering, robotic surgery, clinical medicine, dentistry and other biomedical areas. Hence, the accuracy and precision of the CAD and CAM systems are extremely important for proper treatment. This work suggests a new CAD system for brain image classification by analyzing Magnetic Resonance Images (MRIs) of the brain. Firstly, we use the proposed Downsized Rank Kernel Partial Least Squares (DR-KPLS) as a feature extraction technique. Then, we perform the classification using Support Vector Machines (SVM) and we validate with a k-fold cross validation approach. Further, we utilize the Tabu search metaheuristic approach in order to determine the optimal parameter of the kernel function. The proposed algorithm is entitled DR-KPLS+SVM. The algorithm is tested on the OASIS MRI database. The proposed kernel-based classifier is found to be better performant than the existing methods.

The early detection of Alzheimer’s disease (AD) is essential for improving patient outcomes, enabling timely intervention, and slowing disease progression. However, the complexity of neuroimaging data presents significant obstacles to accurate classification. This study introduces a computationally efficient AI framework designed to enhance AD staging using structural MRI. The proposed method integrates discrete wavelet transform (DWT) for multi-scale feature extraction, a novel reduced kernel partial least squares (Red-KPLS) algorithm for feature reduction, and ResNet-50 for classification. The proposed technique, referred to as Red-KPLS-CNN, refines MRI features into discriminative biomarkers while minimizing redundancy. As a result, the framework achieves 96.9% accuracy and an F1-score of 97.8% in the multiclass classification of AD cases using the Kaggle dataset. The dataset was strategically partitioned into 60% training, 20% validation, and 20% testing sets, preserving class balance throughout all splits. The integration of Red–KPLS enhances feature selection, reducing dimensionality without compromising diagnostic sensitivity. Compared to conventional models, our approach improves classification robustness and generalization, reinforcing its potential for scalable and interpretable AD diagnostics. These findings emphasize the importance of hybrid wavelet–kernel–deep learning architectures, offering a promising direction for advancing computer-aided diagnosis (CAD) in clinical applications.