Objectives: Carbapenem-resistant Gram-negative bacteria (CR-GNB) infections in intensive care units (ICUs) are increasingly prevalent and associated with high mortality. This study aimed to investigate the distribution of isolated bacteria and determine the factors associated with mortality among ICU patients diagnosed with CR-GNB infections. Methods: This retrospective study included 95 patients admitted to the ICU between February 2022 and July 2024 who were diagnosed with CR-GNB infections via culture and initiated on treatment. Thirty-day mortality was defined as the clinical outcome, and patients were divided into two groups: survivors (Group 1, n = 42) and deceased (Group 2, n = 53). Demographic, clinical, laboratory, and microbiological data were analyzed. Results: Advanced age, the presence of malignancy, an elevated Charlson Comorbidity Index (CCI), lower platelet counts, and higher C-reactive protein (CRP) levels were significantly associated with mortality (p < 0.05). Trauma-related admissions were more common among survivors, while sepsis-related admissions predominated among non-survivors. No statistically significant associations were observed between antibiotic regimen type and mortality. Culture-based pathogen distribution revealed A. baumannii as the predominant organism in respiratory samples, while K. pneumoniae was more frequently isolated from bloodstream and urinary specimens. Conclusions: Mortality in ICU patients with CR-GNB infections is influenced by both baseline comorbidities and infection-related inflammatory markers. This study provides region-specific insights from a high-resistance ICU setting and may inform risk stratification, prognostication, and management strategies in critically ill patients with CR-GNB infections.

Objective: This study evaluated the relationships between the development and clinical course of pressure injuries (PIs) and neurological status, nutritional risk, and laboratory parameters among patients admitted to a tertiary intensive care unit. Materials and Methods: The single-center, retrospective, observational study included 220 patients hospitalized in the intensive care unit for at least 5 days. On the day of admission, Glasgow Coma Scale (GCS), Acute Physiology and Chronic Health Evaluation II (APACHE II), Braden, and Nutritional Risk Screening 2002 (NRS-2002) scores were assessed. Demographic characteristics, comorbidities, need for sedation and vasopressors, and laboratory parameters during the first 24 h (albumin, C-reactive protein, lactate, D-dimer) were analyzed. Factors independently associated with new PI development and clinical improvement were identified using binary logistic regression. Results: New PIs developed in 25% of patients. Patients with PI progression were older and had lower GCS and Braden scores, higher NRS-2002 scores, lower albumin levels, and higher D-dimer levels (p < 0.05). In multivariable analysis, low GCS (OR = 0.824), presence of comorbidity (OR = 2.327), and a high NRS-2002 risk level were independent predictors of new PI development. The model’s discriminative ability was acceptable (AUC = 0.756). Among patients with existing PIs, NRS-2002 score (OR = 0.450) and age (OR = 1.058) were independently associated with clinical improvement in an exploratory multivariable model. Conclusions: NRS-2002 was the only variable independently associated with both new PI development and the clinical improvement of existing lesions, underscoring the central role of nutritional risk assessment in ICU-based PI prevention and prognosis.

Aim: The Albumin-Bilirubin (ALBI) score, originally developed to assess liver function in patients with hepatocellular carcinoma, has recently gained attention as a prognostic marker in critically ill patients. This study aimed to evaluate the effectiveness of the ALBI score in predicting mortality among intensive care unit (ICU) patients. Material and Methods: This retrospective study included 157 adult patients admitted to the ICU diverse clinical conditions, including sepsis, respiratory failure, trauma, acute neurological events, and post-cardiac arrest, between November 2023 and November 2024. Clinical data, laboratory parameters, ALBI, SOFA, and APACHE II scores were assessed at ICU admission. The ALBI score is calculated as follows: (log10 bilirubin [μmol/L] × 0.66) + (albumin [g/L] × −0.085). Results: Among the study participants (mean age: 71.7 ± 18.6 years; 55.4% male), 42.7% had diabetes mellitus, 21.7% chronic kidney disease (CKD), 38.9% chronic obstructive pulmonary disease, 73.9% cardiovascular disease, and 19.7% malignancies. The overall mortality rate was 42.7%. Multivariable Cox regression analysis revealed that CKD (HR: 1.90; 95% CI: 1.07–3.39; p = 0.029), higher ALBI scores (HR: 1.65; 95% CI: 1.03–2.65; p = 0.038) and higher APACHE II scores (HR: 1.04; 95% CI: 1.00–1.08; p = 0.031) were independent predictors of mortality. Conclusion: The ALBI score is an independent predictor of mortality among critically ill patients with heterogeneous clinical conditions in general ICU settings. By integrating hepatic dysfunction, nutritional status, and systemic inflammation, ALBI complements traditional prognostic tools and may enhance clinical decision-making and risk stratification.

Mandibulaya künt travmaya sekonder gelişen subaraknoid hemoraji ve bilateral ramus mandibula fraktürü tespit edilen 28 yaşındaki erkek hasta Glaskow Koma Skalası (GKS) 13 olarak genel yoğun bakım ünitesine kabul edildi. Takiplerinde GKS’si 6 ‘ya düşen ve konvülsiyon geçiren hasta acil beyin tomografisi çekilerek ameliyathaneye nakil edildi. Beyin cerrahisi tarafından uygulanan Eksternal ventriküler drenaj (EVD) uygulanması tamamlanarak yoğun bakım ünitesine devredildi.10 günün ardından ekstübe edilen hastanın yoğun bakım sürecinde gelişen EVD menenjiti ve pnömoni tedavileri de tamamlanarak 1 aylık yoğun bakım sürecinin ardından maksillofasiyal cerrahi geçireceği üste merkeze sevk edildi.