Meme kanseri, dünya çapında en yaygın ve ölümcül karsinomlardan biridir ve kadın sağlığı için ciddi bir tehdit oluşturmaktadır. Kötü beslenme, obezite, fiziksel aktivite eksikliği gibi yaşam tarzı faktörlerinin daha yüksek meme kanseri riski ile ilişkili olduğu bilinmektedir. Akdeniz diyeti, temel olarak antioksidanlar ve antiinflamatuvar besinler açısından zengin içeriğe sahip olması nedeniyle dünya çapında en sağlıklı beslenme modellerinden biri olarak kabul edilmektedir. Diyet bileşenlerinin kombinasyonunun; inflamasyonu ve oksidatif stresi azaltmada ortak bir rol oynadığı, dolayısıyla kardiyovasküler hastalıklar ve kanser dahil olmak üzere çeşitli malignitelerin ilerlemesine engel olduğu öne sürülmüştür. Hücrelerin oksidatif ve inflamatuvar süreçlerini azaltmada ve deoksiribo nükleik asit hasarlarını, hücre proliferasyonunu ve hayatta kalmalarını, anjiyogenezleri, inflamasyonu ve metastazları önlemedeki koruyucu etkileri göz önüne alındığında, Akdeniz diyetinin meme kanserinden korunmada ve meme kanseri tedavisinde etkili bir yöntem olabileceği düşünülmektedir. Bu derleme, Akdeniz diyetinin meme kanserinden korunmadaki ve meme kanseri tedavisindeki potansiyel etkilerinin incelenmesi amacıyla yazılmıştır.

MicroRNAs (miRNAs) are key regulators of gene expression and play essential roles in physiological processes such as cell proliferation, apoptosis, and metabolism. They have emerged as promising biomarkers for the early diagnosis, prognosis, and treatment of Metabolic Syndrome (MetS). In recent years, exosome-derived miRNAs, known as “xeno-miRNAs”, which are derived from food, as well as circulating miRNAs, have emerged as areas of intense research due to their potential effects on metabolic disorders. miRNAs influence fasting blood glucose and insulin resistance through mechanisms such as β-cell differentiation, insulin gene transcription, and PI3K–AKT pathway activation. Additionally, miRNAs play important roles in regulating MetS components, as follows: obesity through adipogenesis and lipogenesis; hypertension through regulation of the renin–angiotensin system and vascular tone; and dyslipidemia by modulating lipid metabolism. Emerging evidence suggests that nutrients such as polyphenols and specific dietary patterns can alter miRNA expression, potentially impacting metabolic health. Understanding the interactions between diet and miRNA regulation offers novel insights into the prevention and treatment of MetS. This review explores the mechanisms by which miRNAs influence MetS components, and highlights the growing potential of nutrient-regulated miRNAs as therapeutic targets within the framework of precision nutrition and personalized metabolic disease management.

Objective. This study aimed to determine serum adropin levels and to examine the relationship of serum adropin levels with nutritional status and lipid profile in patients with kidney failure with replacement therapy (KFRT). Methods. The study consisted of 88 subjects, including 30 patients treated with hemodialysis (HD), 29 patients treated with peritoneal dialysis (PD), and 29 patients who had undergone kidney transplantation (TX). The study included assessing anthropometric measurements, handgrip strength, bioelectrical impedance analysis, malnutrition-inflammation score, dietary intake, resting energy expenditure, and biochemical parameters. The patients’ food consumption was recorded for three days. The malnutrition-inflammation score (MIS) was calculated to assess the patients’ nutritional status. Blood samples were collected for serum adropin and other biochemical parameters. Results. Adropin levels were significantly higher in the TX group when compared to the HD group. Patients with low adropin levels had higher MIS, serum ferritin, and lower low-density lipoprotein-cholesterol (LDL-C) and total cholesterol (total-C) levels. Serum adropin levels were negatively correlated with the MIS and positively correlated with total-C, LDL-C, and HDL-C levels. Multiple linear regression analyses showed that the MIS (β=-0.25 p=0.038) and LDL-C level (β=0.29, p=0.007) were associated with serum adropin. Conclusions. Adropin may be considered as a new marker of nutritional status and possibly plays a role in the pathophysiological mechanisms and complications of patients with KFRT.

Breast cancer, a condition that may arise and advance for multiple reasons, is the most prevalent form of cancer among women globally (1). Globocan 2022 data from the International Agency for Resea...

Aims: Nutrition literacy and attitudes toward healthy nutrition are increasingly recognized as factors associated with dietary behavior, including adherence to the Mediterranean diet (MD). However, studies examining these three constructs together, particularly among young adults, remain limited. The purpose of this study was to investigate the relationships between adherence to the MD, nutrition literacy, and healthy nutrition attitudes, and to identify the factors independently associated with healthy nutrition attitudes.Methods: A total of 296 young adults (aged 18-30 years) participated in this cross-sectional study and were recruited through convenience sampling from Erzurum and Kırıkkale, two provinces in Turkiye. Data were collected using face-to-face questionnaires, including the Mediterranean Diet Adherence Screener (MEDAS), The Short Form of the Nutrition Literacy Scale for Young Adults (S-NutLit), and the Attitude Scale for Healthy Nutrition (ASHN). The statistical evaluation of the data was carried out using parametric and nonparametric tests, Chi-square tests, Pearson correlation analysis, and multiple linear regression analysis. Results: Of the participants, 62.8% had acceptable adherence to the MD, and 63.5% self-reported ≥150 minutes of physical activity per week. Male participants had significantly higher total ASHN and positive nutrition (PN) subscale scores than females (p=0.014 and p=0.004, respectively). The S-NutLit score correlated positively with both MEDAS (p