Leprosy has a global presence; more than 180 thousand new cases were registered in 2013, 15% of which were found in the Americas. The elderly are a very susceptible demographic in terms of developing illnesses, mainly because of characteristics natural to the senescence of the human organism. This study’s goals were to analyze leprosy in an elderly population from a hyperendemic region of the Brazilian Amazon in a historical series from 2004 to 2013 and to determine the clinical and epidemiological profile of a series of leprosy cases of elderly people in the period spanning from 2009 to 2013. To achieve these goals, an observational, longitudinal, retrospective and descriptive study was put together to analyze leprosy in elderly people from data acquired from the Notification Aggravations Information System. Furthermore, a profile of the disease from a retrospective cohort based on data collected from medical records was developed. The number of new cases and the leprosy detection rate decreased across the observed period but remained stable among the elderly. The trend for the next ten years indicates decreases in the number of cases and in the detection rate in the general population and an increase in only the elderly. The overall profile was characterized by a predominance of males (64.32%), the multibacillary clinical form (87.57%), Type 1 reaction episodes (37.50%) and some physical incapacity at diagnosis (49.19%). The risk of reaction was greater in the first six months of multidrug therapy, and the positive result from the skin smear was associated with the greater chance of reactional condition development. The resulting data demonstrate that leprosy amongst the elderly deserves attention because of the increased susceptibility to disability in this age group, with their higher risk of reaction and their greater level of co-morbidity. Leprosy, despite being an ancient disease, still represents a challenge to public health systems today. There are still just a few studies about it, particularly among the elderly. It is known that they constitute a very heterogeneous group in terms of immune response to infections, alterations to the peripheral nervous system and predisposition to situations of vulnerability and functional dependency. The Amazon region is a hyperendemic region for leprosy and has been trying to address, along with the rest of Brazil, a rapid increase in the population’s life expectancy. This article surveys medical records from elderly people diagnosed with leprosy in a five-year period at the metropolitan region of Belém, state of Pará (Brazil), identifying a predominance of the multibacillary forms of the disease, a high prevalence of leprosy reactions mainly during treatment with multidrug therapy, and the presence of some physical incapacity in most of the people evaluated. It is expected that this study will contribute to knowledge about the clinical and epidemiological characteristics of leprosy among the elderly and stimulate the making of new studies on the theme.

Resumo Introdução As hepatites virais são graves problemas de saúde pública e estão relacionadas às diferentes características socioeconômicas do território brasileiro. Objetivo Analisar a distribuição espacial das hepatites B e C e sua relação com o Índice de Desenvolvimento Humano Municipal (IDHM) nas áreas de três Centros Regionais de Saúde (CRS), no Estado do Pará, Brasil, de 2010 a 2014. Método Neste trabalho descritivo e transversal, foram utilizados dados do Sistema de Informação de Agravos de Notificação, do Ministério da Saúde, e do Censo 2010, do Instituto Brasileiro de Geografia e Estatística. Resultados As análises mostraram que o 11º CRS notificou o maior número de casos (60,9%). Os indivíduos mais acometidos por ambas as doenças foram do gênero feminino, pardos, adultos e com ensino fundamental. Os fatores de riscos mais significativos foram uso de medicamentos injetáveis e tratamentos dentário e cirúrgico. Foi observada dependência espacial entre o IDHM e os parâmetros da taxa de incidência das doenças, com autocorrelações diretas e indiretas. Assim, áreas com IDHM médio e baixo apresentaram altas taxas de incidência, sobretudo em municípios com intenso fluxo migratório, nas últimas décadas. Conclusão As análises foram eficazes para construir cenários epidemiológicos das doenças. Ressaltamos a necessidade de expandir o controle das hepatites nas áreas estudadas.

Objectives Chronic neuritis (CN) is still a major problem in leprosy and is difficult to manage in patients who do not respond well to prednisone. In this study we (i) evaluate the efficacy of cyclosporine A (CyA) in controlling CN patients, and (ii) analyse the presence of anti-NGF antibodies in the sera of leprosy patients, and their behaviour during CyA treatment. Design This was an open, prospective, non-comparative study. Sixty-seven leprosy patients in three different institutions in Pará, Brazil were studied from January, 2001 to January, 2004. Of these, 47 had no CN and 20 were leprosy patients suffering from CN and taking at least 40 mg/day prednisone to control nerve impairment and pain. Patients received 12 months reducing course CyA starting at 5 mg/kg per day. The outcome measure was sensory impairment, assessed using Semmes–Weinstein monofilament examination (SWME), muscular force and spontaneous or palpation-related pain. Results Antibodies against NGF were detected in the sera of leprosy patients, which may explain the depletion of NGF in leprosy contributing to neuritis, inflammation and loss of cutaneous nociception. The levels of these antibodies in CN patients were slightly lower than in patients with no CN. However, anti-NGF titres in CN patients treated with CyA were lowered to levels similar to those in the normal subjects. There was also improvement in sensory impairment, muscular force and pain. Conclusions These data suggest that anti-NGF antibodies are present in the sera of leprosy patients and may influence the outcome of neuritis, and that CyA might be a useful drug in controlling nerve impairment and pain in leprosy patients.

Introduction: Cutaneous leishmaniasis is an infectious disease transmitted by phlebotomine sandflies and is considered a great environmental and public health problem. Thus, this work presents initial results of the analyses about the relationship between the spatial distribution of this disease and its environmental risk factors in three municipalities, in the state of Pará, Brazil, from 2012 to 2016. Methodology: It was used data from the Ministry of Health, the National Institute for Space Research and the Brazilian Institute of Geography and Statistics. The statistical and spacial analysis of the variables were done using G-test goodness-of-fit, kernel interpolation technique and the Bivariate Global Moran Index (I). Results: The analyses showed that the most affected individuals were males, adults, low schooling, residents in rural areas and small farmers. The disease spatial distribution was not homogeneous in the municipalities and it was associated to different relationships between the land use and occupation and the notificated cases density, with direct spatial autocorrelation. Conclusions: The deforestation was the most significant risk factor linked to the cases occurrence in all the studied area. We emphasize the need of intensification of epidemiological and environmental surveillance actions in the studied areas.

The geographical overlap of HIV (human immunodeficiency virus) and leprosy infection has become increasingly frequent and worrying, bringing many clinical issues. Peripheral neuropathy is very frequent in leprosy because of the predilection of its etiologic agent by Schwann cells of the peripheral nervous system, and it also affects individuals with HIV as one of the most common neurological manifestations. The present study compared a cohort of 63 patients diagnosed with leprosy and coinfected with HIV with a cohort of 64 patients with leprosy alone, who were followed at the outpatient clinic of the Nucleus of Tropical Medicine of the Federal University of Pará, Brazil. We observed that HIV-coinfected leprosy patients presented greater odds of overall peripheral nerve damage (nerve function impairment—NFI) than patients with leprosy alone. More sensitive damage was observed, especially in patients coinfected with multibacillary forms. Leprosy patients coinfected with HIV presented higher chances of motor damage with improvement over time using multidrug therapy (MDT) and highly active antiretroviral therapy (HAART), along with a greater extent of damage and occurrence of neuritis. The data suggest that in addition to patients presenting possible damage caused by leprosy, they also had a greater damage gradient attributable to HIV disease, but not related to HAART because most of these patients had been on the treatment for less than a year. Neuritis was treated with prednisone at doses recommended by the WHO, and coinfected patients had the highest rate of clinical improvement in the first 60 days. The clinical characteristics of the two diseases should be considered in leprosy patients coinfected with HIV for better diagnosis and treatment of peripheral neuropathy. We suggest that new simplified assessment tools that allow the evaluation of the NFI of these patients be developed for use in the service. Coinfections of leprosy and HIV are a challenge for clinical management, particularly concerning peripheral neuropathy, which is common in leprosy and is also present in HIV infection. We conducted a clinical follow-up of leprosy patients coinfected with HIV and compared them to patients with leprosy alone and observed that coinfected patients were more likely to present overall peripheral nerve damage (nerve function impairment—NFI), especially in multibacillary patients, where motor damage was largely responsible for this impairment. Throughout the period using multidrug therapy (MDT) and highly active antiretroviral therapy (HAART), the development of the damage, along with the occurrence of neuritis and complaints, decreased considerably. Thus, the data suggest that in addition to patients presenting possible damage caused by leprosy, they also have a greater damage gradient attributable to the disease due to HIV but not related to HAART. Another important point was the therapeutics used for neuritis with prednisone at doses recommended by the WHO, in which the coinfected patients had the highest rate of clinical improvement in the first 60 days. The characteristics of the two diseases should be considered in the understanding and clinical management of peripheral nerve alterations in leprosy patients coinfected with HIV. In addition, it became clear that further NFI assessment tests should be used with these patients.

Este artigo busca apresentar o desenvolvimento uma ortoprótese de baixo custo com o intuito de auxiliar as funções manuais de indivíduos acometidos pela hanseníase com sequelas de mão em garra com ou sem reabsorção óssea e avaliar seu custo-benefício. Esse processo se deu através do uso dos princípios de alavancas para construção da mecânica do dispositivo, sendo também utilizados materiais alternativos, como fibra de vidro, couro natural e chapa galvanizada para o seu barateamento e fabricação. A partir do emprego dessas, foi possível desenvolver um produto que apresenta excelente benefício mecânico, aliado a um custo reduzido e com design compacto e simplificado, que pode promover a reabilitação e retorno do desempenho das atividades de vida diária de indivíduos acometidos pela hanseníase que tenham sequelas de mão em garra e/ou reabsorção óssea. Quando comparada a meios de fabricação padrão-ouro, como a impressão 3D, ainda assim mostrou-se competitiva com essas, tendo tempo de confecção, redução do esforço necessário para seu uso e o emprego de materiais de baixo custo como maior diferencial em relação as demais.