Domenico Franco

Dr. Domenico Franco

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina,
orcid

Research Focus & Metrics

Academic Career Length

13Years (2014-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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3 September 2022 in Microorganisms
Verified
Journal Article
Open access
PDF file
Domenico FrancoDomenico Franco
Domenico Franco
GCGiovanna Calabrese
Giovanna Calabrese
Salvatore GuglielminoSalvatore Guglielmino
Salvatore Guglielmino
SCSabrina Conoci
Sabrina Conoci
The growing increase in antibiotic-resistant bacteria has led to the search for new antibacterial agents capable of overcoming the resistance problem. In recent years, nanoparticles (NPs) have been increasingly used to target bacteria as an alternative to antibiotics. The most promising nanomaterials for biomedical applications are metal and metal oxide NPs, due to their intrinsic antibacterial activity. Although NPs show interesting antibacterial properties, the mechanisms underlying their action are still poorly understood, limiting their use in clinical applications. In this review, an overview of the mechanisms underlying the antibacterial activity of metal and metal oxide NPs will be provided, relating their efficacy to: (i) bacterial strain; (ii) higher microbial organizations (biofilm); (iii) and physico-chemical properties of NPs. In addition, bacterial resistance strategies will be also discussed to better evaluate the feasibility of the different treatments adopted in the clinical safety fields. Finally, a wide analysis on recent biomedical applications of metal and metal oxide NPs with antibacterial activity will be provided.

1 January 2021 in Materials Science and Engineering: C
Verified
Journal Article
Closed access
GCGiovanna Calabrese
Giovanna Calabrese
SPSalvatore Petralia
Salvatore Petralia
Domenico FrancoDomenico Franco
Domenico Franco
GNGiuseppe Nocito
Giuseppe Nocito
CFClaudia Fabbi
Claudia Fabbi
SCSabrina Conoci
Sabrina Conoci

1 February 2016 in Colloids and Surfaces A: Physicochemical and Engineering Aspects
Verified
Journal Article
Closed access
Enza FazioEnza Fazio
Enza Fazio
MSMarco Santoro
Marco Santoro
GLGermana Lentini
Germana Lentini
Domenico FrancoDomenico Franco
Domenico Franco
Salvatore GuglielminoSalvatore Guglielmino
Salvatore Guglielmino
FNFortunato Neri
Fortunato Neri

1 January 2020 in Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Verified
Journal Article
Closed access
Domenico FrancoDomenico Franco
Domenico Franco
Laura Maria De PlanoLaura Maria De Plano
Laura Maria De Plano
Maria Giovanna RizzoMaria Giovanna Rizzo
Maria Giovanna Rizzo
SSS. Scibilia
S. Scibilia
GLGermana Lentini
Germana Lentini
AMAngela Maria Mezzasalma
Angela Maria Mezzasalma

1 December 2015 in Biosensors and Bioelectronics
Verified
Journal Article
Closed access
GLGermana Lentini
Germana Lentini
Enza FazioEnza Fazio
Enza Fazio
FCFederica Calabrese
Federica Calabrese
Laura Maria De PlanoLaura Maria De Plano
Laura Maria De Plano
MPMaria Puliafico
Maria Puliafico
Salvatore GuglielminoSalvatore Guglielmino
Salvatore Guglielmino

22 March 2024 in Microorganisms
Verified
Journal Article
Open access
PDF file
AIAntonella Iaconis
Antonella Iaconis
Laura Maria De PlanoLaura Maria De Plano
Laura Maria De Plano
ACAntonella Caccamo
Antonella Caccamo
Domenico FrancoDomenico Franco
Domenico Franco
SCSabrina Conoci
Sabrina Conoci
Biofilm (BF) can give rise to systemic infections, prolonged hospitalization times, and, in the worst case, death. This review aims to provide an overview of recent strategies for the prevention and destruction of pathogenic BFs. First, the main phases of the life cycle of BF and maturation will be described to identify potential targets for anti-BF approaches. Then, an approach acting on bacterial adhesion, quorum sensing (QS), and the extracellular polymeric substance (EPS) matrix will be introduced and discussed. Finally, bacteriophage-mediated strategies will be presented as innovative approaches against BF inhibition/destruction.