Understanding the spatiotemporal variations and driving mechanisms of coastlines is crucial for their adequate protection, utilization, and sustainable development. In this study, the changes in various coastline types in Zhuhai from 1987 to 2022 were analyzed by using long-term Landsat and GaoFen satellite imagery. The Index of Coastline Type Diversity (ICTD), Index of Coastline Utilization Degree (ICUD) and the Digital Shoreline Analysis System (DSAS) analysis indicators were employed to investigate coastline change. Both quantitative and qualitative analyses were integrated to comprehensively elucidate the impacts of various driving factors. The results indicate that the total length of Zhuhai coastline increased from 761.50 km in 1987 to 798.91 km in 2022, with natural coastlines decreasing by 89.82 km and artificial coastlines increasing by 153.40 km. The rapid expansion of artificial coastlines since 2007 led to a marked decline in the ICTD indicator, while the ICUD indicator increased from 146.42 in 1987 to 216.37 in 2022, reflecting the intensified and continuous influence of anthropogenic activities. Additionally, the end point rate (EPR) and Weighted Linear Regression Rate (WLR) changed by 8.09 m/yr and 6.62 m/yr, respectively. The Shoreline Change Envelope (SCE) and Net Shoreline Movement (NSM) exhibited average changes of 331.42 m and 224.32 m, respectively. Gray correlation and regression analyses further revealed that climate factors exhibited the strongest association with natural coastline changes, while economic development indicators showed the strongest correlation with artificial coastline dynamics. The relationship of Number of Berths in Main Ports (Nb) with coastline changes strongly suggests that human activities are the primary driver of these changes. These findings provide a robust scientific basis for coastal zone management in Zhuhai.