Sara Alvarez Mokthari

Dr. Sara Alvarez Mokthari

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Research Focus & Metrics

Academic Career Length

3Years (2024-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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4 April 2024 in Cureus
Verified
Journal Article
Open access
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MTManuel Tousidonis
Manuel Tousidonis
SMSara Alvarez Mokthari
Sara Alvarez Mokthari
SKSaad Khayat
Saad Khayat
GMGuillermo Sanjuan de Moreta
Guillermo Sanjuan de Moreta
SOSantiago Ochandiano
Santiago Ochandiano
Silent sinus syndrome is a rare clinical entity affecting the maxillary sinus, characterized by ipsilateral enophthalmos and hypoglobus. Its etiology and pathophysiology are still debated. It is diagnosed by clinical examination and confirmed with computed tomography. It is commonly managed surgically. We present the case of a 34-year-old woman with silent sinus syndrome treated with a patient-specific implant for orbital reconstruction, functional endoscopic sinus surgery approach, intraoperative scan, and surgical navigation, successfully restoring orbital volume and sinus ventilation.

12 August 2025 in Life
Verified
Journal Article
Open access
PDF file
Gonzalo Ruiz-de-LeónGonzalo Ruiz-de-León
Gonzalo Ruiz-de-León
SOSantiago Ochandiano
Santiago Ochandiano
SMSara Alvarez Mokthari
Sara Alvarez Mokthari
MBMarta Benito
Marta Benito
INIsmael Nieva-Pascual
Ismael Nieva-Pascual
MTManuel J. Tousidonis
Manuel J. Tousidonis
Graves’ orbitopathy (GO) is a debilitating autoimmune disorder that may require surgical orbital decompression in severe cases with risk of proptosis and optic neuropathy. This report presents a case treated with navigation-assisted three-wall orbital decompression, planned with preoperative imaging and assessed using postoperative analysis. Intraoperative navigation enabled precise localization of critical structures, improving osteotomy execution. Postoperatively, orbital volume increased by 3.5 cm3 (right eye) and 4.0 cm3 (left eye), while proptosis was reduced by 6 mm in both eyes. These changes correlated with intraocular pressure normalization and functional improvement. This was further supported by a postoperative Clinical Activity Score (CAS) of 0, indicating active orbital inflammation. Image-guided surgery (IGS) achieved an average proptosis reduction of 3.8 mm, slightly superior to that of non-guided techniques. Although IGS enhances precision and functional outcomes, it requires longer surgical time and incurs higher costs, highlighting the need for prospective studies on long-term efficacy This case supports the importance of integrating advanced imaging and navigation-assisted techniques in GO management to improve both functional and aesthetic outcomes.

23 January 2026 in Journal of Clinical Medicine
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Journal Article
Open access
PDF file
Gonzalo Ruiz-de-LeónGonzalo Ruiz-de-León
Gonzalo Ruiz-de-León
MTManuel J. Tousidonis
Manuel J. Tousidonis
JSJose-Ignacio Salmeron
Jose-Ignacio Salmeron
RPRuben Perez-Mañanes
Ruben Perez-Mañanes
SMSara Alvarez Mokthari
Sara Alvarez Mokthari
SOSantiago Ochandiano
Santiago Ochandiano
Background: Orbital dermoid cysts are common benign lesions; however, deep-seated or recurrent lesions near the orbital apex pose major surgical challenges due to their proximity to critical neurovascular structures. Lateral orbitotomy remains the reference approach, but accurate osteotomies and stable reconstruction can be difficult to achieve using conventional techniques. This study reports our initial experience using a fully digital, hospital-based point-of-care (POC) workflow to enhance precision and safety in complex orbital dermoid cyst surgery. Methods: We present a case series of three patients with orbital dermoid cysts treated at a tertiary center (2024–2025) using a comprehensive digital workflow. Preoperative assessment included CT and/or MRI followed by virtual surgical planning (VSP) with orbit–tumor segmentation and 3D modeling. Cutting guides and patient-specific implants (PSIs) were manufactured in-house under a certified hospital-based POC protocol. Surgical strategies were tailored to each lesion and included piezoelectric osteotomy, intraoperative navigation, intraoperative CT, and structured-light scanning when indicated. Results: Complete en bloc resection was achieved in all cases without capsular rupture or optic nerve injury. Intraoperative CT confirmed complete lesion removal and accurate PSI positioning and fitting. Structured-light scanning enabled radiation-free postoperative monitoring when used. All patients preserved full ocular motility, visual acuity, and facial symmetry, with no complications or recurrences during follow-up. Conclusions: The integration of VSP, in-house POC manufacturing, and image-guided surgery within a lateral orbitotomy approach provides a reproducible and fully integrated workflow. This strategy appears to improve surgical precision and safety while supporting optimal long-term functional and aesthetic outcomes in challenging orbital dermoid cyst cases.