This paper explores the application and evolution of Configuration Risk Management (CRM) systems in Chinese nuclear power plants, focusing on their alignment with the National Nuclear Safety Administration (NNSA)’s technical policies. It examines how CRM integrates risk management action matrices, risk limits, and monitoring tools to manage risks effectively across both second-generation plants with a higher baseline Core Damage Frequency (CDF) and third-generation plants with a lower baseline CDF. The study highlights the significant advancements in CRM system development, including the improvement of risk monitoring tools and the establishment of standardized technical guidelines, and underscores the critical role of ongoing regulatory support and CRM system enhancement to ensure the safe and sustainable operation of nuclear power plants in China, offering valuable insights for future nuclear safety management.