This study investigates a heavy-duty CNC machine tool crossbeam casting manufactured by a leading heavy machine tool producer. A numerical simulation model for the demolding process was developed using proprietary Computer-Aided Engineering (CAE) software. The experimental validation of the residual stress was performed using the blind-hole method on the guide rail mounting surface. The simulation results were compared with experimental data, revealing that the post-demolding simulations exhibited smaller fluctuations than the pre-demolding predictions. The maximum principal stress prediction resulted in an absolute error of 11.8%, effectively reflecting the residual stress distribution for casting design and production optimization.