With the increasing analysis of saving the environment, the researchers demonstrated much effort to replace toxic chemicals with environmentally benign ones. Eutectic mixtures are those solvents that fulfill the criteria of green solvents. The synthesis of organic compounds in the chemical and pharmaceutical industries makes it necessary to find unconventional solvents that cause no harmful impact on health parameters. This review showed that using deep eutectic mixture-based solvents to overcome the hazardous effects of harmful volatile organic solvents over the past few years has gained much more appeal. In most applications, deep eutectic mixtures are used for a solvent or co-solvent role, as they are easy to use, easy dissolution of reactants, and non-evaporative nature. However, deep eutectic mixtures have also been investigated as catalysts, and this dual functionality has much scope in the future, as a significantly less range of deep eutectic mixtures is utilized for this.

Green synthesis of iron oxide nanoparticles using Argemone mexicana leaf extract serves as a sustainable route. The biosynthesized nanoparticles exhibit strong antioxidant activity, demonstrating potential for therapeutic applications.

Isoxazole and its derivatives derived from natural resources are very few. However, they have several applications in pharmaceutical industries, including antimicrobial, antitumor, anticancer, antifungal, and antibacterial activities. As a result, this research aimed to design a novel one-pot green approach to synthesize new oxazole derivatives. The derivatives were further explored for their antibacterial and antioxidant activities together with their density functional theory (DFT) analysis. Characterization of newly synthesized moieties was done by IR, ¹H NMR, ¹³C NMR, CHN analysis, & single-crystal X-ray Crystallography. Further, these compounds were examined for their antibacterial potential by using Gentamycin as a standard drug against S. aureus and E. coli bacterial strains. The derivatives 4a, 4c, 4d, 4f, 4j, and 4k possessed excellent antibacterial potential against former, while 4c and 5 showed the highest activity against the later one. The derivatives were also analyzed for their antioxidant activities by using free radical scavenging (ABTS. & DPPH assays), and total antioxidant capacity. Here also, 4a, 4d, 4e, 4k, 4l, 4m, and 5 exhibited the most promising results. Finally, the DFT analysis was achieved by using the B3LYP methodology with a 6–311 + G(d,p) basis set to study the electronic structure of molecules and analysis of chemical reactivity descriptors such as hardness (η), Mulliken electronegativity (χ), chemical potential (μ) and electrophilicity (ω). These properties were calculated from the levels of the predicted frontier molecular orbitals and their energy gap.

: The history of tri-substituted methanes (TRSMs) in chemical industries is much older. Tri-substituted methanes were previously used as dyes in the chemical industries. Still, there is a significant surge in researchers' interest in them due to their wide range of bioactivities. Tri-substituted methane derivatives show a wide range of biological activities like anti-tumor, antimicrobial, antibiofilm, antioxidant, anti-inflammatory, anti-arthritic activities. Due to the wide range of medicinal applications shown by tri-substituted methanes, most of the methodologies reported in the literature for the synthesis of TRSMs are focused on the one-pot method. This review explored the recently reported one-pot processes for synthesizing tri-substituted methanes and their various medicinal applications. Based on the substitution attached to the -CH carbon, this review categorizes them into two major classes: (I) symmetrical and (II) unsymmetrical trisubstituted methanes. In addition, this review gives an insight into the growing opportunities for the construction of trisubstituted scaffolds via one-pot methodologies. To the best of our knowledge, no one has yet reported a review on the one-pot synthesis of TRSMs. Therefore, here we present a brief literature review of the synthesis of both symmetrical and unsymmetrical TRSMs covering various one-pot methodologies along with their medicinal applications.

Because of its miscellaneous properties, developing less environmentally hazardous and trustworthy methodologies has become one of the most crucial steps toward synthesizing nanoparticles (NPs) among researchers and scientists. In this direction, silver nanoparticles (AgNPs or SNPs) have gained much attention because of their anti-inflammatory, antibacterial, antiviral, and antifungal properties, potential toxicity, and unusual physicochemical features. Concerning the toxicity of silver nanoparticles, silver nanoparticles may prove to be an essential tool against many drugresistant microorganisms and substitutes for antibiotics. However, the synthesis of AgNPs using conventional methods had a toxic impact and caused much damage to the ecosystem. Researchers have used various production techniques to prevent the adverse effects of toxic chemicals, including algae, bacteria, fungi, and plants. This review study has covered recent advancements in green synthetic methodologies for synthesizing AgNPs. This insight provides a comprehensive overview of key findings in the green synthesis of Ag nanoparticles and attempts to focus on factors affecting their synthesis, characterization, applications, potential toxic impact on living organisms, merits/ demerits, and prospects.

The synthesis of coumarin derivatives has been an essential topic since its discovery in 1820. In bioactive compounds, the coumarin moiety serves as a backbone, as many such bioactive compounds with the coumarin moiety play a significant role in their bioactivities. Given this moie-ty's relevance, several researchers are developing fused-coumarin derivatives to create new drugs. Mostly the approach done for this purpose was a multicomponent reaction based. Over the years, the multicomponent reaction has gained enormous popularity, and this approach has evolved as a replacement for conventional synthetic methods. Because of all these perspectives, we have report-ed the various fused-coumarin derivatives synthesized using multicomponent reactions in recent years.