Alina Mariana Paraschiv

Dr. Alina Mariana Paraschiv


Research Focus & Metrics

Academic Career Length

4Years (2023-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 June 2023 in Healthcare
Verified
Journal Article
Open access
PDF file
DVDragoș Vulcănescu
Dragoș Vulcănescu
VGVeronica Gheorman
Veronica Gheorman
DPDaniel-Cristian Pîrvu
Daniel-Cristian Pîrvu
VDVenera Cristina Dinescu
Venera Cristina Dinescu
GVGheorman Victor
Gheorman Victor
Mircea-Catalin FortofoiuMircea-Catalin Fortofoiu
Mircea-Catalin Fortofoiu
The research article highlights the significance of acute myocardial infarction (AMI) and its impact on depression and anxiety among patients’ post-primary percutaneous coronary interventions (PCI). The study aims to determine the frequency of depression and anxiety occurrence in patients with acute myocardial infarction after primary PCI. The objective of this study is to investigate the frequency of depression and anxiety in patients with acute myocardial infarction after primary PCI. The method used in the study involved the collection of data from 88 patients with acute myocardial infarction who underwent primary PCI treatment. The patients were tested before PCI and then at intervals of 1 month, 6 months, and 12 months post-PCI using the Hamilton Depression Scale (HAM-D17) and the Hamilton Anxiety Scale (HAM-A) to identify depression and anxiety symptoms, respectively. The study performed a comprehensive analysis of the collected data to determine the frequency of depression and anxiety occurrence in post-PCI patients. The study found evidence that primary PCI reduces depression and anxiety in patients who have experienced a myocardial infarction. However, mental health issues continue to be a significant psychological concern for patients post-PCI, impacting their lifestyle, self-care, and treatment adherence. The study suggests that healthcare providers should actively screen and manage psychiatric disorders in patients who have suffered from AMI as they are at an increased risk of mental disorders. In conclusion, the study indicates that depression and anxiety are common issues in acute myocardial infarction survivors, and interventions addressing these conditions should be a routine part of care. The study highlights the need for healthcare providers to be aware of the increased risk of mental disorders in individuals who have suffered from AMI. Understanding the impact of anxiety and depression on post-PCI patients is essential for the development of effective interventions that support patients’ recovery.

25 December 2024 in Biomedicines
Verified
Journal Article
Open access
PDF file
DTDespina Manuela Toader
Despina Manuela Toader
APAlina Mariana Paraschiv
Alina Mariana Paraschiv
GTGeorgică Târtea
Georgică Târtea
GTGabriela TIUCU
Gabriela TIUCU
MCMihai Chițu
Mihai Chițu
OMOana Munteanu Mirea
Oana Munteanu Mirea
Background/Objectives: This study aimed to evaluate layer-specific strain according to etiology and assess whether subtle changes in longitudinal and circumferential layer strain are involved in predicting cardiac mortality during a two-year follow-up in patients with dilated cardiomyopathy admitted with heart failure decompensation. Methods: 97 patients with dilated cardiomyopathy and a left ventricle ejection fraction ≤ 40% were recruited, 51 with ischemic and 46 with nonischemic etiologies. Conventional and two-dimensional speckle-tracking echocardiography (2D-STE) were conducted in dilated cardiomyopathy patients with a compensated phase of heart failure before discharge. Layer-specific longitudinal and circumferential strain was assessed from the endocardium, mid-myocardium, and epicardium by two-dimensional (2D) speckle-tracking echocardiography. The gradient between the endocardium and epicardium was calculated. Results: Patients with nonischemic etiology of dilated cardiomyopathy presented smaller values of global and layer strain than patients in the ischemic group. GLS, GLSend, GLSend-GLSepi, CSPMend, CSPMend-CSPMepi, CSAP, CSAPend, and CSAPend-CSAPepi were the parameters with statistically significant decreased values in non-survivors compared with survivors. In multivariate analysis, only CSPMend showed an independent value in predicting mortality at two-year follow-up. Receiver operator curve analysis provided CSPMend of −10.8% as a cut-off value with a sensitivity of 80% and specificity of 61.05% in identifying the dilated cardiomyopathy and heart failure patients with a risk of death at two-year follow-up. Conclusions: GLS, GCS, and layer-specific strain analysis showed decreased values in nonischemic compared with ischemic dilated cardiomyopathy and also in non-survivors compared with survivors. CSPMend was the most sensitive strain parameter to identify patients with increased mortality risk at two-year follow-up.

17 July 2025 in Biomedicines
Verified
Journal Article
Open access
PDF file
DTDespina Manuela Toader
Despina Manuela Toader
APAlina Mariana Paraschiv
Alina Mariana Paraschiv
DHDiana Ruxandra Hădăreanu
Diana Ruxandra Hădăreanu
MIMaria Livia Iovănescu
Maria Livia Iovănescu
OMOana Munteanu Mirea
Oana Munteanu Mirea
ACAlina Craciun-Mirescu
Alina Craciun-Mirescu
Background/Objectives: Anatomical and functional damage of the mitral valve (MV) apparatus in patients with dilated cardiomyopathy (DCM) is secondary to left ventricular (LV) injury, leading to functional mitral regurgitation (FMR). Real-time four-dimensional echocardiography (RT 4DE) is a useful imaging technique in different pathologies, including DCM. Left atrial (LA) strain, as measured by left atrium quantification software, is an accurate technique for evaluating increased filling pressure. The MV has a complex three-dimensional morphology and motion. Four-dimensional echocardiography (4DE) has revolutionized clinical imaging of the mitral valve apparatus. This study aims (1) to characterize the mitral annulus (MA) parameters in patients with DCM and advanced-stage heart failure (HF) according to etiology and (2) to find correlations between left atrial function and MA remodeling in this group of patients, using 4DE quantification software. Methods: A total of 82 patients with DCM and an LV ejection fraction ≤ 40% were recruited. Conventional 2DE and RT 4DE were conducted in DCM patients with a compensated phase of HF before discharge. The measured parameters were left atrial reservoir strain (LASr), annular area (AA), annular perimeter (AP), anteroposterior diameter (A-Pd), posteromedial to anterolateral diameter (PM-ALd), commissural distance (CD), interregional distance (ITD), annular height (AH), nonplanar angle (NPA), tenting height (TH), tenting area (TA), and tenting volume (TV). Results: Measured parameters revealed more advanced damage of LA and MA parameters in ischemic compared to nonischemic etiology. Univariate analysis identified AA, AP, A-Pd, PM-ALd, CD, ITD, TH, TA, and TV (p < 0.0001) as determinants of LASr. Including these parameters in a stepwise multivariate logistic regression, PM-ALd (p = 0.03), TH (p = 0.043), and TV (p = 0.0001) were the best predictors of LAsr in these patients. Conclusions: The results of this study revealed the correlation between LA function depression and MA remodeling in patients with DCM.

27 August 2025 in Cureus
Verified
Journal Article
Open access
PDF file
APAlina Mariana Paraschiv
Alina Mariana Paraschiv
DTDespina M. Toader
Despina M. Toader
CFCristina Florescu
Cristina Florescu
DTDiana Rodica Tudorascu
Diana Rodica Tudorascu
TBTudor Adrian Balseanu
Tudor Adrian Balseanu
We will present the case of a young man with a respiratory condition lasting for several months, treated with anti-inflammatory drugs and antibiotics, who, following an abdominal ultrasound that revealed pericardial fluid, was referred to the Emergency Department of Filantropy Hospital. Serological tests and imaging investigations were performed to establish the diagnosis and etiology. The first imaging impact was the echocardiogram, which revealed suggestive features of constrictive pericarditis, later confirmed through cardiac magnetic resonance imaging. Due to advanced symptoms, right heart failure phenomena, with hepatomegaly and grade 3 Lewis jugular vein distension, the initial treatment was with intravenous loop diuretics at a low dose and a sodium-glucose cotransporter-2 (SGLT2) inhibitor, but with poor tolerance due to a drop in blood pressure. For this reason, the patient was urgently referred to the Cardiovascular Surgery Department, where the case was resolved through pericardiectomy. The histopathological examination did not reveal a specific etiology as the cause of the constrictive pericarditis. The patient's postoperative evolution and paraclinical investigations showed a favorable status. Timely surgical intervention for this patient made the difference between symptom worsening and the potential onset of complications, and the successful resolution of the case.