The electrocardiogram (ECG) remains a cornerstone of modern cardiology, providing rapid, non-invasive, and widely accessible diagnostic insights. While ECG interpretation is an essential skill for clinicians, certain patterns can be subtle or atypical, posing diagnostic challenges. In our previous review (doi.org/10.3390/jpm12111754), we explored several uncommon ECG syndromes with significant clinical implications. However, the spectrum of electrocardiographic abnormalities extends far beyond those initially discussed. In this second installment, we expand our discussion of rare and underrecognized ECG syndromes, including Long QT, Jervell and Lange-Nielsen, Romano–Ward, Andersen–Tawil, Timothy, Short QT, and Twiddler’s syndromes, as well as Noonan, Barlow’s, Bundgaard, BRASH, Carvajal, Naxos, and Danon disease. We highlight their clinical context, characteristic findings, and implications for diagnosis and management. These conditions range from acute, life-threatening emergencies requiring immediate intervention to chronic electrical disorders necessitating long-term monitoring and risk stratification. By broadening our focus, we aim to enhance awareness and recognition of these entities, ultimately improving patient outcomes through timely and accurate diagnosis.

Dyslipidemia is a characteristic feature of nephrotic syndrome (NS), which significantly increases the risk of cardiovascular complications and progression of chronic kidney disease. This review analyzes current understanding of the complex pathophysiological mechanisms of lipid metabolism disorders in NS. Particular attention is paid to the impact of proteinuria on the synthesis of lipoproteins by the liver and impaired clearance. The article systematizes current therapeutic strategies. Therapeutic prospects aimed at correcting the lipid profile as a means of nephroprotection are considered. The review emphasizes the need for a personalized approach to the management of dyslipidemia, taking into account the etiology of NS and the functional state of the kidneys.