Hyperglycemia, as well as diabetes mellitus, has been shown to trigger cardiac cell apoptosis. We have previously demonstrated that myricitrin prevents endothelial cell apoptosis. However, whether myricitrin can attenuate H9c2 cell apoptosis remains unknown. In this study, we established an experiment model in H9c2 cells exposed to high glucose. We tested the hypothesis that myricitrin may inhibit high glucose (HG)-induced cardiac cell apoptosis as determined by TUNEL staining. Furthermore, myricitrin promoted antioxidative enzyme production, suppressed high glucose-induced reactive oxygen species (ROS) production and decreased mitochondrial membrane potential (MMP) in H9c2 cells. This agent significantly inhibited apoptotic protein expression, activated Akt and facilitated the transcription of NF-E2-related factor 2 (Nrf2)-mediated protein (heme oxygenase-1 (HO-1) and quinone oxidoreductase 1 (NQO-1) expression as determined by Western blotting. Significantly, an Akt inhibitor (LY294002) or HO-1 inhibitor (ZnPP) not only inhibited myricitrin-induced HO-1/NQO-1 upregulation but also alleviated its anti-apoptotic effects. In summary, these observations demonstrate that myricitrin activates Nrf2-mediated anti-oxidant signaling and attenuates H9c2 cell apoptosis induced by high glucose via activation of Akt signaling.

Corrigendum on: Zhang B, Zhang J, Zhang C, Zhang X, Ye J, Kuang S, Sun G and Sun X (2018) Notoginsenoside R1 Protects Against Diabetic Cardiomyopathy Through Activating Estrogen Receptor α and Its Downstream Signaling. Front. Pharmacol. 9:1227Pharmacol. 9: . doi: 10.3389/fphar.2018.01227 .01227 In the published article, there was an error in Figures 2F, Figure 3A, E and Figures 8C as published. Specifically, Western blot pictures of HO-1and NQO-1 in Figure 2F were misplaced.After checking the raw data, the misplaced Western blot pictures of HO-1and NQO-1 were corrected. The corrected Figures 2 and its caption appears below.In the published article, there was an error in Figures 3A,E. The TUNEL staining picture in AGEs group was misplaced in Figures 3A. Additionally, the Western blot pictures of Bcl-2 and cleaved casp-3 were misplaced in Figure 3E. After checking the raw data, the misplaced bands of Bcl-2 and cleaved casp-3 were corrected. The misplaced Lamin B1 and β-actin bands in Figure 8C were also corrected. The corrected Figures 3 and8 and its caption appears below. and HO-1) showed that NGR1 promoted the translocation of Nrf2 to the nucleus. This was associated with the up-regulation of these anti-oxidant enzymes. The quantitative data are presented as the mean ± SD (n = 3). ## P < 0.01 vs. the Control group, * P < 0.05 or ** P < 0.01 vs. the AGEs group.The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

In the original article [1], the authors identified that Fig. 9 and Fig. 10 in the article used the wrong images because of incorrect figure assembly. In Fig. 9A, the ROS fluorescence image of sophocarpine-10 μM was the same as that of cytisine-50 μM. The authors identified that the image of cytisine-50 μM was uploaded incorrectly, and the correct ROS fluorescence and bright field image of cytisine-50 μM in reassembled Fig. 9 were provided. In Fig. 10, the intracellular calcium fluorescence image of matrine-10 μM was the same as that of matrine-50 μM. The authors identified that the image of matrine-10 μM was uploaded incorrectly, and the correct calcium fluorescence and bright field image of matrine-10 μM in the reassembled Fig. 10 were provided.