Aim: This research suggested an in vitro virucidal action of a dental gel and a mouthwash with phthalocyanine derivative. Purpose: The aim of this study was to report an in vitro study evaluating the virucidal capacity of mouthwash and dental gel containing anionic phthalocyanine derivate (APD). Methods: The research followed the recommendations of the National Health Surveillance Agency (ANVISA) and adapted methodology, described in the standards EN14776: 2015; ASTM E1053-11 and the Robert Koch Institute – RKI, in addition to good laboratory practices (GLP). The determination of the percentage of inactivation of the SARS-CoV-2 virus particles was carried out by imposing the viral solution in contact with the respective tested products, with intervals of 30 seconds, 1 and 5 minutes, with subsequent submission of the aliquots, recovered in cell culture microplates following virus titration using the TCID50 (50% Median Tissue Culture Infectious Dose). Results: The Mouthwash APD presented 90% of viral inactivation percentage, while the dental gel APD demonstrated 99.99% of viral inactivation. Conclusion: In vitro analyses showed that mouthwash and dental gel APD can reduce the viability of SARS-CoV-2 virus particles.

Aim: This case series demonstrated that phthalocyanine derivate mouthwash is a promising alternative for reducing the viral load of SARS-CoV-2 and for clinical improvement of infected patients who presented mild and moderate symptoms. Purpose: The aim of this study was to report a case series of patients diagnosed with COVID-19 that used the phthalocyanine derivate mouthwash to reduce clinical symptoms. Patients and Methods: Eight patients used 5mL of phthalocyanine derivate mouthwash gargling/rinsing for one minute, five times daily, over a fourteen day period. Two measurement scales were applied for each patient in different periods to verify sore throat – VAS – Visual Analogue Scale for Pain and the clinical conditions – PS – Performance Status. Results: All patients presented a significant reduction in clinical symptoms with the use of the mouthwash for gargling/rinsing after few days of use, without hospitalization. Conclusion: The phthalocyanine derivate mouthwash protocol appears as a potential alternative for clinical improvement of COVID-19 infected patients. Daily use of this mouthwash rapidly reduced clinical symptoms such as sore throats, cough and mouth ulcers. Large, high-quality randomized controlled trials with larger sample size are necessary to confirm the effectiveness of this mouthwash protocol against COVID-19.

Dear Editor, It has been well established in science that the mouth is an entry and site of replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the coronavirus 2019 disease (COVID-19). Hence, oral health care and use of broad-spectrum antimicrobial products become relevant.() Recently the use of phthalocyanine derivative mouthwash (PDM), has been investigated, demonstrating in vitro activity in reduction of viral load of SARS-CoV-2, in addition to clinical improvement and less severe disease, with no [...] Dear Editor, It has been well established in science that the mouth is an entry and site of replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the coronavirus 2019 disease (COVID-19). Hence, oral health care and use of broad-spectrum antimicrobial products become relevant.() Recently the use of phthalocyanine derivative mouthwash (PDM), has been investigated, demonstrating in vitro activity in reduction of viral load of SARS-CoV-2, in addition to clinical improvement and less severe disease, with no

The present study aimed to evaluate the in vitro antiseptic efficacy of a mouthwash and a dental gel containing phthalocyanine derivatives (Pc) against bacteria and fungi frequently found in patients with ventilator-associated pneumonia. The experiment in this study was conducted following Good Laboratory Practices. The product was tested at concentrations of 0.015% (mouthwash) and 0.100% (dental gel). The contact time of the suspension test (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella sp., Candida albicans, and Aspergillus niger) was 60 s (1 min). In this analysis, the Phtalox® Mouthwash and Dental Gel resulted in a 99.99% reduction against the tested microorganisms after 1 min of contact time in both products. The Pc-containing mouthwash and dental gel were effective against bacteria and fungi found in patients with ventilator-associated pneumonia.

Objectives: This study aimed to evaluate the association between nutritional status and oral health-related quality of life (OHRQoL) in older adults from population-based studies of two cities in southern Brazil. Methods: A total of 569 community-dwelling individuals aged 60 years and older were included. Sociodemographic, dental, and behavioral data were collected. Nutritional status was evaluated using the Mini Nutritional Assessment (MNA). OHRQoL, the primary outcome, was measured using the Oral Health Impact Profile-14 (OHIP-14) questionnaire. Poisson regression with robust variance was applied in crude and adjusted analyses to evaluate the impact of nutritional status on OHIP-14 outcomes. Results: The prevalence of risk of malnutrition was 31.6%, while the mean OHIP-14 was 4.86 ± 7.55. Individuals with malnutrition risk (7.44 ± 9.95) showed overall OHIP-14 scores significantly higher than those with normal nutrition (3.65 ± 5.76) (p < 0.001). A similar trend in results was detected in all domains of OHIP-14 (p < 0.05). In the adjusted analysis, individuals at risk of malnutrition had a 66% higher prevalence ratio (PR) (95% confidence interval [95% CI]: 1.23–2.23) of having poorer OHRQoL. Associations were also observed for the severity (PR: 1.69; 95% CI: 1.31–2.19) and extent (PR: 2.33; 95% CI: 1.55–3.49) of OHIP-14. Conclusions: In conclusion, poorer nutritional status is significantly associated with a higher impact on OHRQoL in older adults.

This study presents a case report of a patient with chronic kidney disease (CKD) with secondary hyperparathyroidism and the presence of manifestations in the oral-maxillofacial complex with Renal osteodystrophy (ROD). Also, a literature review in the PubMed was carried out using the MeSH Terms descriptors (((jaws) AND (treatment)) AND (secondary hyperparathyroidism)) AND (case reports). The search was limited to articles written in English and published in the last 10 years. Also, this article presented the clinical case of a 49- year-old caucasian female patient, with volumetric increase in jaws after dental extraction. The patient reported having CKD for 10 years. Clinical examination of the patient revealed enlargement of the alveolar bone ridge in the maxilla and mandible. The maxilla showed an evident loss of palatal concavity, and the mandible loss of space at the bottom of the vestibular groove. The diagnosis of ROD was consolidated after the analysis of imaging tests, laboratory tests and histopathological evaluation of the bone tissue. The manifestation of systemic diseases in the face demands a systemic look, to establish treatments with the best prognosis. We reinforce the need for multidisciplinary work for the correct diagnosis and management of patients with systemic diseases.