Male infertility is a multifactorial condition often associated with disruptions in sperm metabolism and mitochondrial function, yet traditional semen analysis provides limited insight into these molecular mechanisms. Understanding sperm bioenergetics and metabolic dysfunctions is crucial for improving the diagnosis and treatment of conditions such as asthenozoospermia and azoospermia. This systematic review synthesizes recent literature, focusing on advanced tools and techniques—including omics technologies, advanced imaging, spectroscopy, and functional assays—that enable comprehensive molecular assessment of sperm metabolism and development. The reviewed studies highlight the effectiveness of metabolomics, proteomics, and transcriptomics in identifying metabolic biomarkers linked to male infertility. Non-invasive imaging modalities such as Raman and magnetic resonance spectroscopy offer real-time metabolic profiling, while the seminal microbiome is increasingly recognized for its role in modulating sperm metabolic health. Despite these advances, challenges remain in clinical validation and implementation of these techniques in routine infertility diagnostics. Integrating molecular metabolic assessments with conventional semen analysis promises enhanced diagnostic precision and personalized therapeutic approaches, ultimately improving reproductive outcomes. Continued research is needed to standardize biomarkers and validate clinical utility. Furthermore, these metabolic tools hold significant potential to elucidate the underlying causes of previously misunderstood and unexplained infertility cases, offering new avenues for diagnosis and treatment.

Tuberculosis constitutes a major public health problem in the world. Certain extra-pulmonary locations of tuberculosis disease are very exceptional. Amongst these, tuberculosis of the breast is rare even in countries where this infection is endemic. This form of tuberculosis is characterized by clinical and radiological polymorphisms and might mimic other diseases, especially breast cancer. This retrospective study is entailing seventeen patients treated in the Onco-Gynecology Department of the Mohammed VI Cancer Treatment Center, in the Ibn Rochd University Hospital of Casablanca, for breast tuberculosis, over a period of three years. We report the epidemiological, clinical and paraclinical aspects and we specify the treatment and evolution of the patients.

Background Endometrial cancer is the fourth most common cancer in women in high-income countries and its incidence has increased over the past 20 to 30 years. In Morocco, the incidence is close to those found in developing countries, but it is lower than those found in Western countries. To determine some epidemiological aspects of endometrial cancer in Morocco, we conducted a prospective study over 43 months at the International University Hospital Cheikh Khalifa and the Mohammed VI Center for Cancer Treatment at the Ibn Rochd Casablanca University Hospital, Morocco. 93 cases of endometrial cancer were included. Results The average age was 64. 36.5% of our patients had early menarche. 17.2% had menstrual cycle abnormalities. The nulliparous patients represent 40.8℅. 3 patients in our series underwent medical hormone treatment. 46.2% of patients claimed to have taken oral contraception during their period of genital activity, 79.5℅ were obese, 62.3% of the patients are diabetic and 49.4% are known to be hypertensive. 9.6% of patients are on hormone therapy with Tamoxifen. Metrorrhagia is the first symptom encountered in 62.2% of cases. Ultrasound was performed on all of our first-line patients and pelvic MRI was the most relevant examination in the pre-therapeutic assessment of endometrial cancer. Endometrial adenocarcinoma of the endometriotic type (81.72%) was the most prominent histological type. The therapeutic attitudes practiced were: Extended total colpohysterectomy for 17 patients. Total hysterectomy with bilateral salpingo-oophorectomy for 93 patients. Omentectomy was performed for 11 patients. 78 patients had undergone pelvic lymph node dissection, while 51 patients had undergone an associated lumbarortic dissection. 44.08℅ of cases were diagnosed at stage (IA) and 18.27℅ of cases at stage (III). At the time when we stopped our study, 42 patients had received radiotherapy as adjuvant treatment, ie 45.1% of cases. Conclusions Local and locoregional epidemiological studies should be multiplied to shed light on the interest of prevention by promoting a healthy lifestyle. Besides, genetic studies must be conducted to better understand the place of racial factors as risk factors for this cancer.

Male infertility is a multifactorial condition often associated with disruptions in sperm metabolism and mitochondrial function, yet traditional semen analysis provides limited insight into these molecular mechanisms. Understanding sperm bioenergetics and metabolic dysfunctions is crucial for improving diagnosis and treatment of conditions such as asthenozoospermia and azoospermia.Methods: This systematic review synthesizes recent literature, focusing on novel tools and techniques—including omics technologies, advanced imaging, spectroscopy, and functional assays—that enable comprehensive molecular assessment of sperm metabolism and development.Results: The reviewed studies highlight the effectiveness of metabolomics, proteomics, and transcriptomics in identifying metabolic biomarkers linked to male infertility. Non-invasive imaging modalities such as Raman and magnetic resonance spectroscopy offer real-time metabolic profiling, while the seminal microbiome is increasingly recognized for its role in modulating sperm metabolic health. Despite these advances, challenges remain in clinical validation and implementation of these techniques in routine infertility diagnostics.Conclusions: Integrating novel molecular metabolic assessments with conventional semen analysis promises enhanced diagnostic precision and personalized therapeutic approaches, ultimately improving reproductive outcomes. Continued research is needed to standardize biomarkers and validate clinical utility. Furthermore, these metabolic tools hold significant potential to elucidate the underlying causes of previously misunderstood and unexplained infertility cases, offering new avenues for diagnosis and treatment.