Sleep is a fundamental biological process in athletes, indispensable for tissue regeneration, exercise adaptation, and injury prevention. Disruptions in sleep architecture and duration have been consistently associated with diminished physical performance and adverse health outcomes, impairing muscular strength, power output, and endurance capacity, and concurrently compromising cognitive function. On a physiological level, insufficient sleep disrupts endocrine homeostasis, elevating cortisol levels and reducing anabolic hormones such as testosterone and growth hormone. At the molecular level, sleep loss promotes the upregulation of pro-apoptotic gene expression and exacerbates pro-inflammatory signalling pathways. Optimal sleep duration and quality represent a critical “regenerative window”, essential for enhancing athletic performance and safeguarding physiological resilience. Ensuring adequate sleep among athletes can be effectively achieved through educational, behavioural, and nutritional interventions outlined in this review.

Immunotherapy has revolutionized cancer treatment; however, the availability of cost-effective blood-based biomarkers for prognostic and predictive factors of immune treatment in patients with solid tumors remains limited. Due to low cost and easy accessibility, blood-based biomarkers should constitute an essential component of studies to optimize and monitor immunotherapy. Currently available markers that can be measured in peripheral blood include total monocyte count, myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs), relative eosinophil count, cytokine levels (such as IL-6, IL-8, and IL-10), lactate dehydrogenase (LDH), C-reactive protein (CRP), soluble forms of CTLA-4 and PD-1 or PD-L1, as well as circulating tumor DNA (ctDNA). In our mini-review, we discuss the latest evidence indicating that routinely accessible peripheral blood parameters—such as the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), and rheological parameters, which so far have been rarely considered for such an application, may be used as non-invasive biomarkers in cancer immunotherapy. Rheological parameters such as whole blood viscosity are influenced by several factors, such as hematocrit, aggregability and deformability of erythrocytes, and plasma viscosity, which is largely dependent on plasma proteins. Especially in cases where the set of symptoms indicates a high probability of hyperviscosity syndrome, blood rheological tests can lead to early diagnosis and treatment. Both biochemical and rheological parameters are prone to become novel and future standards for assessing immunotherapy among patients with solid tumors.

Background. Some reports suggest that cardiac surgery may require monitoring of the patients' hemorheological parameters such as whole blood viscosity (WBV), plasma viscosity (PV), hematocrit (HCT), shear stress and shear rate.. Aim. This review article focuses on changes in hemorheological parameters of blood accompanying surgery for heart valve defects (focusing on aortic stenosis and mitral annulus calcification), coronary artery bypass grafting (CABG), surgical treatment of endocarditis and transplantations. Material and methods. A comprehensive literature search was conducted using PubMed, Google Scholar and Web of Science with Key words. Results. Patients who have undergone surgical treatment for heart valve defects suggest that changes in hemorheological parameters may correlate with a higher risk of postoperative death or the development of complications. Conclusions. Considering the studies discussed in this article, hemorheological parameters may become significant indicators of the patient's condition and prognosis in the future, but the research is not complete yet.

Background and objectives: It is now increasingly acknowledged that psychological resilience and effective stress management are important factors in determining performance in professional sport. The present review examines various psychological interventions used in sport psychology, with particular emphasis on methods for improving performance under competitive pressure. It also assesses the psychometric scales and paradigm-based tools available for measuring stress, stress reactivity, and pre-competition anxiety in athletes. Methods: A narrative review was carried out using the OVID, EBSCO, PubMed, SCOPUS, Web of Science, and Google Scholar databases, with a preference for randomised controlled trials, observational studies, systematic reviews, meta-analyses, and consensus guidelines. Results: The results form the foundation for creating more thorough athlete support programmes. Psychological interventions are necessary to improve or maintain sporting performance, manage stress and anxiety, promote healthy sleep habits, and reduce the risk of injury. Conclusions: Athletic performance is influenced by technical, tactical, physical, and psychological factors. Psychological interventions, including self-talk, imagery, goal setting, mindfulness, and relaxation techniques, help manage stress while maintaining focus and motivation. It is recommended that athlete sleep education and psychosocially informed injury prevention be incorporated into these strategies.